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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleMetabolomic Investigation Of Human Diseases Biomarkers By Ce And Lc Coupled To Ms.pt_BR
dc.contributor.authorBuzatto, Adriana Zpt_BR
dc.contributor.authorde Sousa, Ana Carolinapt_BR
dc.contributor.authorGuedes, Sumaya Fpt_BR
dc.contributor.authorCieslarová, Zuzanapt_BR
dc.contributor.authorSimionato, Ana Valéria Cpt_BR
unicamp.authorAdriana Z Buzatto, Institute of Chemistry, University of Campinas - Unicamp, Campinas, Brazil.pt_BR
unicamp.author.externalAna Carolina de Sousa,pt
unicamp.author.externalSumaya F Guedes,pt
unicamp.author.externalZuzana Cieslarová,pt
unicamp.author.externalAna Valéria C Simionato,pt
dc.subjectBiological Markerspt_BR
dc.subjectChromatography, Liquidpt_BR
dc.subjectDiabetes Mellituspt_BR
dc.subjectElectrophoresis, Capillarypt_BR
dc.subjectHumanspt_BR
dc.subjectMass Spectrometrypt_BR
dc.subjectMetabolomicspt_BR
dc.subjectNeoplasmspt_BR
dc.subjectNervous System Diseasespt_BR
dc.subjectBiomarkerspt_BR
dc.subjectCancerpt_BR
dc.subjectDiabetespt_BR
dc.subjectKidney Diseasept_BR
dc.subjectNeurological Diseasespt_BR
dc.description.abstractMetabolomics is one of the most recent trends in the omics era that investigates the end products of an organism activity, that is, all metabolites in a biological system, which are small molecules (less than 1000 Da) from different chemical classes. Metabolomics represents a tool to assess the biochemical activity of a living system through the analysis of substrates and products processed during the metabolism. The analysis of the metabolic profile (nontargeted analysis, i.e. a comparison between samples profiles of individuals) and of specific metabolites (targeted analysis, which quantifies a selected group of metabolites) in biological samples provides an insight into the metabolic state and the biochemical processes of the organism and, therefore, may indicate the onset and the stage of different diseases. An early and accurate diagnosis is essential for successful treatment and probable cure of most illnesses; hence, the investigation of metabolites as disease biomarkers has increased considerably in recent years. This review aims to present the most relevant works that address the nontargeted and targeted analysis of metabolites in different diseases for the past 10 years, including kidney and neurological disorders, cardiovascular diseases, diabetes, and cancer, using CE and LC coupled with the accurate detection of mass spectroscopy.en
dc.relation.ispartofElectrophoresispt_BR
dc.relation.ispartofabbreviationElectrophoresispt_BR
dc.date.issued2014-Maypt_BR
dc.identifier.citationElectrophoresis. v. 35, n. 9, p. 1285-307, 2014-May.pt_BR
dc.language.isoengpt_BR
dc.description.volume35pt_BR
dc.description.firstpage1285-307pt_BR
dc.rightsfechadopt_BR
dc.rights.holder© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1522-2683pt_BR
dc.identifier.doi10.1002/elps.201300470pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24375663pt_BR
dc.date.available2015-11-27T13:41:42Z-
dc.date.accessioned2015-11-27T13:41:42Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:41:42Z (GMT). No. of bitstreams: 1 pmed_24375663.pdf: 437215 bytes, checksum: 24291ac395050b305ba2f5e1299214b3 (MD5) Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201064-
dc.identifier.idPubmed24375663pt_BR
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