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Type: Artigo de periódico
Title: Stathmin 1 Is Involved In The Highly Proliferative Phenotype Of High-risk Myelodysplastic Syndromes And Acute Leukemia Cells.
Author: Machado-Neto, João Agostinho
de Melo Campos, Paula
Favaro, Patricia
Lazarini, Mariana
Lorand-Metze, Irene
Costa, Fernando Ferreira
Olalla Saad, Sara Teresinha
Traina, Fabiola
Abstract: Stathmin 1 is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of Stathmin 1 expression have been reported in leukemia and solid tumors. However, Stathmin 1 has not been studied in myelodysplastic syndrome cells. We, herein, report that significantly higher Stathmin 1 levels were observed in proliferating hematopoietic cells, in high-risk MDS and acute leukemia cells. In addition, Stathmin 1 silencing in U937 and Namalwa leukemia cells reduced cell proliferation and clonogenicity. Our data suggest that Stathmin 1 expression may be related to the highly proliferative phenotype of hematopoietic cells and add new insights into the participation of Stathmin 1 in hematological malignancies.
Subject: Adolescent
Aged, 80 And Over
Cell Proliferation
Leukemia, Myeloid, Acute
Middle Aged
Myelodysplastic Syndromes
Neoplasm Invasiveness
Tumor Cells, Cultured
U937 Cells
Young Adult
Acute Lymphoid Leukemia
Acute Myeloid Leukemia
Myelodysplastic Syndromes
Stathmin 1
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2013.11.013
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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