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dc.typeArtigo de periódicopt_BR
dc.titleEmergence Of Extended-spectrum β-lactamase Producing Enterobacter Spp. In Patients With Bacteremia In A Tertiary Hospital In Southern Brazil.pt_BR
dc.contributor.authorNogueira, Keite da Silvapt_BR
dc.contributor.authorPaganini, Maria Cristinapt_BR
dc.contributor.authorConte, Andréiapt_BR
dc.contributor.authorCogo, Laura Lúciapt_BR
dc.contributor.authorTaborda de Messias Reason, Iarapt_BR
dc.contributor.authorda Silva, Márcio Josépt_BR
dc.contributor.authorDalla-Costa, Libera Mariapt_BR
unicamp.authorMárcio José da Silva, Plant Molecular Biology and Genomics of Campinas University (Unicamp), Campinas, Brazil.pt_BR da Silva Nogueira, Clinics Hospital, Federal University of Paraná (UFPR), Curitiba, Brazilpt Program in Pharmaceutical Sciences of UFPR, Curitiba, Cristina Paganini, Clinics Hospital, Federal University of Paraná (UFPR), Curitiba,éia Conte, Medical Course of UFPR, Curitiba, Lúcia Cogo, Clinics Hospital, Federal University of Paraná (UFPR), Curitiba, Taborda de Messias Reason, Clinics Hospital, Federal University of Paraná (UFPR), Curitiba, Brazilpt Program in Pharmaceutical Sciences of UFPR, Curitiba, Maria Dalla-Costa, Clinics Hospital, Federal University of Paraná (UFPR), Curitiba, Brazilpté Pequeno Príncipe Faculty and Research Institute (FPP/IPPPP), Curitiba, Brazil. Electronic address:
dc.subjectBeta-lactamasas De Espectro Extendidopt_BR
dc.subjectExtended-spectrum β-lactamasept_BR
dc.description.abstractExtended-spectrum β-lactamases (ESBLs) are increasingly prevalent in Enterobacter spp., posing a challenge to the treatment of infections caused by this microorganism. The purpose of this retrospective study was to evaluate the prevalence, risk factors, and clinical outcomes of inpatients with bacteremia caused by ESBL and non ESBL-producing Enterobacter spp. in a tertiary hospital over the period 2004-2008. The presence of blaCTX-M, blaTEM, blaSHV, and blaPER genes was detected by polymerase chain reaction (PCR) and nucleotide sequence analysis. Genetic similarity between strains was defined by pulsed-field gel electrophoresis (PFGE). Enterobacter spp. was identified in 205 of 4907 of the patients who had positive blood cultures during hospitalization. Of those cases, 41 (20%) were ESBL-producing Enterobacter spp. Nosocomial pneumonia was the main source of bacteremia caused by ESBL-producing Enterobacter spp. The presence of this microorganism was associated with longer hospital stays. The ESBL genes detected were: CTX-M-2 (23), CTX-M-59 (10), CTX-M-15 (1), SHV-12 (5), and PER-2 (2). While Enterobacter aerogenes strains showed mainly a clonal profile, Enterobacter cloacae strains were polyclonal. Although no difference in clinical outcomes was observed between patients with infections by ESBL-producing and non-ESBL-producing strains, the detection of ESBL in Enterobacter spp. resulted in the change of antimicrobials in 75% of cases, having important implications in the decision-making regarding adequate antimicrobial therapy.en
dc.relation.ispartofEnfermedades Infecciosas Y Microbiología Clínicapt_BR
dc.relation.ispartofabbreviationEnferm. Infecc. Microbiol. Clin.pt_BR
dc.identifier.citationEnfermedades Infecciosas Y Microbiología Clínica. v. 32, n. 2, p. 87-92, 2014-Feb.pt_BR
dc.rights.holderCopyright © 2012 Elsevier España, S.L. All rights reserved.pt_BR
dc.description.provenanceMade available in DSpace on 2015-11-27T13:41:38Z (GMT). No. of bitstreams: 1 pmed_23587705.pdf: 684183 bytes, checksum: 05e91b5964347bc6d7f0bab91e925dd2 (MD5) Previous issue date: 2014en
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