Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201040
Type: Artigo
Title: Neuropsychiatric symptoms in Alzheimer's disease are related to functional connectivity alterations in the salience network
Author: Pereira, F.R.S.
Balthazar, M.L.F.
Silva, E.L. da
Campos, B.M.
Lopes, T.M.
Duncan, N.W.
Damasceno, B.P.
Northoff, G.
Cendes, F.
Stella, F.
Coan, A.C.
Abstract: Neuropsychiatric syndromes are highly prevalent in Alzheimer's disease (AD), but their neurobiology is not completely understood. New methods in functional magnetic resonance imaging, such as intrinsic functional connectivity or resting-state analysis, may help to clarify this issue. Using such approaches, alterations in the default-mode and salience networks (SNs) have been described in Alzheimer's, although their relationship with specific symptoms remains unclear. We therefore carried out resting-state functional connectivity analysis with 20 patients with mild to moderate AD, and correlated their scores on neuropsychiatric inventory syndromes (apathy, hyperactivity, affective syndrome, and psychosis) with maps of connectivity in the default mode network and SN. In addition, we compared network connectivity in these patients with that in 17 healthy elderly control subjects. All analyses were controlled for gray matter density and other potential confounds. Alzheimer's patients showed increased functional connectivity within the SN compared with controls (right anterior cingulate cortex and left medial frontal gyrus), along with reduced functional connectivity in the default-mode network (bilateral precuneus). A correlation between increased connectivity in anterior cingulate cortex and right insula areas of the SN and hyperactivity syndrome (agitation, irritability, aberrant motor behavior, euphoria, and disinhibition) was found. These findings demonstrate an association between specific network changes in AD and particular neuropsychiatric symptom types. This underlines the potential clinical significance of resting state alterations in future diagnosis and therapy.
Neuropsychiatric syndromes are highly prevalent in Alzheimer's disease (AD), but their neurobiology is not completely understood. New methods in functional magnetic resonance imaging, such as intrinsic functional connectivity or "resting-state" analysis,
Subject: Doença de Alzheimer
Imagem por ressonância magnética
Testes neuropsicológicos
Análise de regressão
Country: Estados Unidos
Editor: John Wiley & Sons
Citation: Human Brain Mapping. v. 35, n. 4, p. 1237-46, 2014-Apr.
Rights: fechado
Identifier DOI: 10.1002/hbm.22248
Address: https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.22248
Date Issue: 2014
Appears in Collections:FCM - Artigos e Outros Documentos

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