Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201040
Type: Artigo de periódico
Title: Neuropsychiatric Symptoms In Alzheimer's Disease Are Related To Functional Connectivity Alterations In The Salience Network.
Author: Balthazar, Marcio L F
Pereira, Fabrício R S
Lopes, Tátila M
da Silva, Elvis L
Coan, Ana Carolina
Campos, Brunno M
Duncan, Niall W
Stella, Florindo
Northoff, Georg
Damasceno, Benito P
Cendes, Fernando
Abstract: Neuropsychiatric syndromes are highly prevalent in Alzheimer's disease (AD), but their neurobiology is not completely understood. New methods in functional magnetic resonance imaging, such as intrinsic functional connectivity or resting-state analysis, may help to clarify this issue. Using such approaches, alterations in the default-mode and salience networks (SNs) have been described in Alzheimer's, although their relationship with specific symptoms remains unclear. We therefore carried out resting-state functional connectivity analysis with 20 patients with mild to moderate AD, and correlated their scores on neuropsychiatric inventory syndromes (apathy, hyperactivity, affective syndrome, and psychosis) with maps of connectivity in the default mode network and SN. In addition, we compared network connectivity in these patients with that in 17 healthy elderly control subjects. All analyses were controlled for gray matter density and other potential confounds. Alzheimer's patients showed increased functional connectivity within the SN compared with controls (right anterior cingulate cortex and left medial frontal gyrus), along with reduced functional connectivity in the default-mode network (bilateral precuneus). A correlation between increased connectivity in anterior cingulate cortex and right insula areas of the SN and hyperactivity syndrome (agitation, irritability, aberrant motor behavior, euphoria, and disinhibition) was found. These findings demonstrate an association between specific network changes in AD and particular neuropsychiatric symptom types. This underlines the potential clinical significance of resting state alterations in future diagnosis and therapy.
Subject: Aged
Alzheimer Disease
Brain Mapping
Humans
Magnetic Resonance Imaging
Nerve Fibers, Unmyelinated
Neural Pathways
Neuropsychological Tests
Psychiatric Status Rating Scales
Regression Analysis
Rest
Alzheimer's Disease
Default Mode Network
Functional Connectivity
Neuropsychiatric Symptoms
Salience Network
Rights: fechado
Identifier DOI: 10.1002/hbm.22248
Address: http://www.ncbi.nlm.nih.gov/pubmed/23418130
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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