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Type: Artigo de periódico
Title: The Effects Of 780-nm Low-level Laser Therapy On Muscle Healing Process After Cryolesion.
Author: Brunelli, Roberta M
Rodrigues, Natalia C
Ribeiro, Daniel A
Fernandes, Kelly
Magri, Angela
Assis, Lívia
Parizotto, Nivaldo A
Cliquet, Alberto
Renno, Ana Claudia M
Abreu, Daniela C C
Abstract: The objective of this study was to assess the effects of 780-nm low-level laser therapy at different periods of 7, 14 and 21 days after cryolesion, including the dose (10 or 50 J/cm(2)), to promote a better muscle repair evidenced by histopathological and immunohistochemical analyses. Fifty-four male rats were divided into three groups: injured control group (CG)-injured animals without any treatment; injured 780-nm laser-treated group, at 10 J/cm(2) (G10); and injured 780-nm laser-treated group, at 50 J/cm(2) (G50). Each group was divided into three subgroups (n = 6): 7, 14 and 21 days post-injury. Histopathological findings revealed better organised muscle fibres in the G10 and G50 during the periods of 7 and 14 days compared to the CG. The G10 and G50 during the 7 days showed a significant reduction (p < 0.05) of lesion area compared to the CG, without differences between groups treated for 14 and 21 days. The G10 showed an increase of the amount of vessels after 14 days compared to the G50, but not in relation to controls. With regard to the immunohistochemical analyses of the MyoD factor, the G10 and G50 during the 7 days showed higher concentrations of immunomarkers than controls. Myogenin immunomarkers were similarly observed at days 7 and 14 in all the three groups analysed, whereas immunomarkers were found in none of the groups after 21 days of laser therapy. The results showed that laser, regardless the applied dose, has positive effects on muscle repair.
Subject: Animals
Biological Markers
Disease Models, Animal
Laser Therapy, Low-level
Muscle, Skeletal
Myod Protein
Rats, Wistar
Time Factors
Wound Healing
Citation: Lasers In Medical Science. v. 29, n. 1, p. 91-6, 2014-Jan.
Rights: fechado
Identifier DOI: 10.1007/s10103-013-1277-6
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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