Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201025
Type: Artigo de periódico
Title: Effects Of Atorvastatin And T-786c Polymorphism Of Enos Gene On Plasma Metabolic Lipid Parameters.
Author: Zago, Vanessa Helena de Souza
Santos, José Eduardo Tanus dos
Danelon, Mirian Regina Gardin
Silva, Roger Marcelo Mesquita da
Panzoldo, Natália Baratella
Parra, Eliane Soler
Alexandre, Fernanda
Virgínio, Vítor Wilson de Moura
Quintão, Eder Carlos Rocha
Faria, Eliana Cotta de
Abstract: Endothelial nitric oxide synthase (eNOS) activity may be modulated by high-density lipoprotein cholesterol (HDL-C), statins or polymorphisms, such as the T-786C of eNOS. This study aimed at evaluating if the T-786C polymorphism is associated with changes of atorvastatin effects on the lipid profile, on the concentrations of metabolites of nitric oxide (NO) and of high sensitivity C-reactive protein (hsCRP). Thirty male volunteers, asymptomatic, aged between 18 and 56 years were genotyped and classified according to absence (TT, n = 15) or presence (CC, n = 15) of the polymorphism. They were randomly selected for the use of placebo or atorvastatin (10 mg/day/14 days). After each treatment lipids, lipoproteins, HDL2 and HDL3 composition, cholesteryl ester transfer protein (CETP) activity, metabolites of NO and hsCRP were evaluated. The comparisons between genotypes after placebo showed an increase in CETP activity in a polymorphism-dependent way (TT, 12±7; CC, 22±12; p < 0.05). The interaction analyses between treatments indicated that atorvastatin has an effect on cholesterol, LDL, nitrite and lipid-protein ratios (HDL2 and HDL3) (p < 0.001) in both genotypes. Interestingly, we observed genotype/drug interactions on CETP (p < 0.07) and lipoprotein (a) (Lp(a)) (p < 0.056), leading to a borderline decrease in CETP, but with no effect on Lp(a). HsCRP showed no alteration. These results suggest that statin treatment may be relevant for primary prevention of atherosclerosis in patients with the T-786C polymorphism of eNOS, considering the effects on lipid metabolism.
Subject: Adolescent
Adult
Analysis Of Variance
C-reactive Protein
Cholesterol Ester Transfer Proteins
Heptanoic Acids
Humans
Lipid Metabolism
Lipids
Male
Middle Aged
Nitric Oxide
Nitric Oxide Synthase Type Iii
Polymorphism, Genetic
Pyrroles
Single-blind Method
Statistics, Nonparametric
Treatment Outcome
Young Adult
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/23250834
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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