Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200886
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePtk2 And Ptpn11 Expression In Myelodysplastic Syndromes.pt_BR
dc.contributor.authorLazarini, Marianapt_BR
dc.contributor.authorMachado-Neto, João Agostinhopt_BR
dc.contributor.authorArchangelo, Leticia Fröhlichpt_BR
dc.contributor.authorMendes-Silva, Bruna Fernandespt_BR
dc.contributor.authorBigarella, Carolina Louzãopt_BR
dc.contributor.authorTraina, Fabiolapt_BR
dc.contributor.authorSaad, Sara Teresinha Olallapt_BR
unicamp.authorMariana Lazarini, Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, CampinasSP, Brazil.pt_BR
unicamp.author.externalJoão Agostinho Machado-Neto,pt
unicamp.author.externalLeticia Fröhlich Archangelo,pt
unicamp.author.externalBruna Fernandes Mendes-Silva,pt
unicamp.author.externalCarolina Louzão Bigarella,pt
unicamp.author.externalFabiola Traina,pt
unicamp.author.externalSara Teresinha Olalla Saad,pt
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectAgedpt_BR
dc.subjectAged, 80 And Overpt_BR
dc.subjectBone Marrow Cellspt_BR
dc.subjectFemalept_BR
dc.subjectFocal Adhesion Kinase 2pt_BR
dc.subjectFocal Adhesion Protein-tyrosine Kinasespt_BR
dc.subjectHumanspt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectMyelodysplastic Syndromespt_BR
dc.subjectPolymerase Chain Reactionpt_BR
dc.subjectPrognosispt_BR
dc.subjectProtein Tyrosine Phosphatase, Non-receptor Type 11pt_BR
dc.subjectRisk Factorspt_BR
dc.subjectStatistics, Nonparametricpt_BR
dc.subjectYoung Adultpt_BR
dc.subjectSrc Homology Domainspt_BR
dc.description.abstractThe aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors. Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells. Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors.en
dc.relation.ispartofClinics (são Paulo, Brazil)pt_BR
dc.relation.ispartofabbreviationClinics (Sao Paulo)pt_BR
dc.date.issued2013-Octpt_BR
dc.identifier.citationClinics (são Paulo, Brazil). v. 68, n. 10, p. 1371-5, 2013-Oct.pt_BR
dc.language.isoengpt_BR
dc.description.volume68pt_BR
dc.description.firstpage1371-5pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1980-5322pt_BR
dc.identifier.doi10.6061/clinics/2013(10)13pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24212846pt_BR
dc.date.available2015-11-27T13:32:19Z-
dc.date.accessioned2015-11-27T13:32:19Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:32:19Z (GMT). No. of bitstreams: 1 pmed_24212846.pdf: 307036 bytes, checksum: 9c4cb4835aa286c9003eaabc6a577c81 (MD5) Previous issue date: 2013en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200886-
dc.identifier.idPubmed24212846pt_BR
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