Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200886
Type: Artigo de periódico
Title: Ptk2 And Ptpn11 Expression In Myelodysplastic Syndromes.
Author: Lazarini, Mariana
Machado-Neto, João Agostinho
Archangelo, Leticia Fröhlich
Mendes-Silva, Bruna Fernandes
Bigarella, Carolina Louzão
Traina, Fabiola
Saad, Sara Teresinha Olalla
Abstract: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors. Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells. Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors.
Subject: Adolescent
Adult
Aged
Aged, 80 And Over
Bone Marrow Cells
Female
Focal Adhesion Kinase 2
Focal Adhesion Protein-tyrosine Kinases
Humans
Male
Middle Aged
Myelodysplastic Syndromes
Polymerase Chain Reaction
Prognosis
Protein Tyrosine Phosphatase, Non-receptor Type 11
Risk Factors
Statistics, Nonparametric
Young Adult
Src Homology Domains
Rights: aberto
Identifier DOI: 10.6061/clinics/2013(10)13
Address: http://www.ncbi.nlm.nih.gov/pubmed/24212846
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_24212846.pdf299.84 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.