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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePrognostic Indicators For Long-term Disability In Multiple Sclerosis Patients.pt_BR
dc.contributor.authorDamasceno, Alfredopt_BR
dc.contributor.authorVon Glehn, Felipept_BR
dc.contributor.authorBrandão, Carlos Otáviopt_BR
dc.contributor.authorDamasceno, Benito Pereirapt_BR
dc.contributor.authorCendes, Fernandopt_BR
unicamp.authorAlfredo Damasceno, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. alfredodamasceno@hotmail.compt_BR
unicamp.author.externalFelipe Von Glehn,pt
unicamp.author.externalCarlos Otávio Brandão,pt
unicamp.author.externalBenito Pereira Damasceno,pt
unicamp.author.externalFernando Cendes,pt
dc.subjectAdultpt_BR
dc.subjectAge Of Onsetpt_BR
dc.subjectAgedpt_BR
dc.subjectBrain Stempt_BR
dc.subjectBrazilpt_BR
dc.subjectDisability Evaluationpt_BR
dc.subjectDisease Progressionpt_BR
dc.subjectEducational Statuspt_BR
dc.subjectEthnic Groupspt_BR
dc.subjectFemalept_BR
dc.subjectFollow-up Studiespt_BR
dc.subjectHumanspt_BR
dc.subjectKaplan-meier Estimatept_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectMultiple Sclerosispt_BR
dc.subjectMultiple Sclerosis, Relapsing-remittingpt_BR
dc.subjectPrognosispt_BR
dc.subjectRecurrencept_BR
dc.subjectRegression Analysispt_BR
dc.subjectSex Factorspt_BR
dc.subjectSocioeconomic Factorspt_BR
dc.subjectSurvival Analysispt_BR
dc.subjectTreatment Outcomept_BR
dc.subjectUrban Populationpt_BR
dc.description.abstractDaily practice is still faced with uncertainty in predicting the long-term disability of multiple sclerosis (MS). Most information comes from northern hemisphere cohorts, but in South America this information is scarce, and race, genetic and environmental factors could play an important role in the heterogeneity observed in disease outcomes. We evaluated 197 patients attending our MS Center gathering clinical and demographic information. Outcome measures analyzed were time from first clinical symptom to EDSS of 6, 7 and 8. For survival analysis we employed Cox regression models and the Kaplan-Meier method. Time to EDSS 6 was 25.83 years (95% CI 15.36-36.31), and 36.25 years (95% CI 20.72-51.78) for EDSS 7. Male sex was associated with a 4.63 and 4.69 fold increased risk to EDSS 6 and 7, respectively (p<0.001 and p=0.006). Motor and brainstem symptoms at onset were also associated with an 8.1 and 13.1 fold increased risk to EDSS 6, respectively (p=0.04 and p=0.01). The number of relapses in five and ten years of disease onset was associated with a slightly increased risk to EDSS 8 (1.28 and 1.19, respectively; p=0.032 and p=0.015). Male patients presenting with frequent relapses, especially those with motor and brainstem involvement, deserve close observation and should be cautiously monitored to early signs of treatment failure.en
dc.relation.ispartofJournal Of The Neurological Sciencespt_BR
dc.relation.ispartofabbreviationJ. Neurol. Sci.pt_BR
dc.date.issued2013-Janpt_BR
dc.identifier.citationJournal Of The Neurological Sciences. v. 324, n. 1-2, p. 29-33, 2013-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume324pt_BR
dc.description.firstpage29-33pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2012 Elsevier B.V. All rights reserved.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1878-5883pt_BR
dc.identifier.doi10.1016/j.jns.2012.09.020pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23073568pt_BR
dc.date.available2015-11-27T13:32:14Z-
dc.date.accessioned2015-11-27T13:32:14Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:32:14Z (GMT). No. of bitstreams: 1 pmed_23073568.pdf: 411448 bytes, checksum: 8e37243e5ca4656e1de5e0a9c21350e2 (MD5) Previous issue date: 2013en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200852-
dc.identifier.idPubmed23073568pt_BR
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