Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200838
Type: Artigo de periódico
Title: Effect Of Neovestitol-vestitol Containing Brazilian Red Propolis On Accumulation Of Biofilm In Vitro And Development Of Dental Caries In Vivo.
Author: Bueno-Silva, B
Koo, H
Falsetta, M L
Alencar, S M
Ikegaki, M
Rosalen, P L
Abstract: The present study examined the influences of the neovestitol-vestitol (NV) containing fraction isolated from Brazilian red propolis on the development of biofilm and expression of virulence factors by Streptococcus mutans using saliva-coated surfaces of hydroxyapatite. In addition, NV was tested in a rodent model of dental caries to assess its potential effectiveness in vivo. Topical applications of NV (800 μg ml(-1)) significantly impaired the accumulation of biofilms of S. mutans by largely disrupting the synthesis of glucosyltransferase-derived exopolysaccharides and the expression of genes associated with the adaptive stress response, such as copYAZ and sloA. Of even greater impact, NV was as effective as fluoride (positive control) in reducing the development of carious lesions in vivo. NV is a promising natural anti-biofilm agent that targets essential virulence traits in S. mutans, which are associated with the formation of cariogenic biofilm and the subsequent onset of dental caries disease.
Subject: Animals
Biofilms
Biofouling
Dental Caries
Flavonoids
Gene Expression Profiling
Glucosyltransferases
Oligonucleotide Array Sequence Analysis
Propolis
Rna, Bacterial
Rats
Rats, Wistar
Streptococcus Mutans
Virulence Factors
Rights: fechado
Identifier DOI: 10.1080/08927014.2013.834050
Address: http://www.ncbi.nlm.nih.gov/pubmed/24099330
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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