Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200824
Type: Artigo de periódico
Title: Guava Pomace: A New Source Of Anti-inflammatory And Analgesic Bioactives.
Author: Denny, Carina
Melo, Priscilla S
Franchin, Marcelo
Massarioli, Adna P
Bergamaschi, Keityane B
de Alencar, Severino M
Rosalen, Pedro L
Abstract: Guava pomace is an example of the processing waste generated after the manufacturing process from the juice industry that could be a source of bioactives. Thus, the present investigation was carried out in order to evaluate the anti-inflammatory and antinociceptive potential and determinate the main phenolic compounds of a guava pomace extract (GPE). The anti-inflammatory activity was evaluated by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models. Acetic acid-induced abdominal writhing and formalin test were performed to investigate the antinociceptive effects. In addition, the content of total phenolic and of individual phenolic compounds was determined by GC/MS. GPE showed anti-inflammatory activity by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models (p < 0.05). GPE also demonstrated antinociceptive activity by acetic acid-induced abdominal writhing and formalin test (p < 0.05). The total phenolic value was 3.40 ± 0.09 mg GAE/g and epicatechin, quercetin, myricetin, isovanilic and gallic acids were identified by GC/MS analysis. The presence of bioactive phenolic compounds as well as important effects demonstrated in animal models suggest that guava pomace could be an interesting source of anti-inflammatory and analgesic substances.
Subject: Analgesics
Animals
Anti-inflammatory Agents
Behavior, Animal
Formaldehyde
Industrial Waste
Male
Mice
Mice, Inbred Balb C
Neutrophils
Pain Measurement
Peritoneal Cavity
Plant Extracts
Psidium
Rights: aberto
Identifier DOI: 10.1186/1472-6882-13-235
Address: http://www.ncbi.nlm.nih.gov/pubmed/24063346
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_24063346.pdf276.03 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.