Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200789
Type: Artigo de periódico
Title: Thalamic Metabolic Abnormalities In Patients With Huntington's Disease Measured By Magnetic Resonance Spectroscopy.
Author: Casseb, R F
D'Abreu, A
Ruocco, H H
Lopes-Cendes, I
Cendes, F
Castellano, G
Abstract: Huntington's disease (HD) is a neurologic disorder that is not completely understood; its fundamental physiological mechanisms and chemical effects remain somewhat unclear. Among these uncertainties, we can highlight information about the concentrations of brain metabolites, which have been widely discussed. Concentration differences in affected, compared to healthy, individuals could lead to the development of useful tools for evaluating the progression of disease, or to the advance of investigations of different/alternative treatments. The aim of this study was to compare the thalamic concentration of metabolites in HD patients and healthy individuals using magnetic resonance spectroscopy. We used a 2.0-Tesla magnetic field, repetition time of 1500 ms, and echo time of 135 ms. Spectra from 40 adult HD patients and 26 control subjects were compared. Quantitative analysis was performed using the LCModel method. There were statistically significant differences between HD patients and controls in the concentrations of N-acetylaspartate+N-acetylaspartylglutamate (NAA+NAAG; t-test, P<0.001), and glycerophosphocholine+phosphocholine (GPC+PCh; t-test, P=0.001) relative to creatine+phosphocreatine (Cr+PCr). The NAA+NAAG/Cr+PCr ratio was decreased by 9% and GPC+PCh/Cr+PCr increased by 17% in patients compared with controls. There were no correlations between the concentration ratios and clinical features. Although these results could be caused by T1 and T2 changes, rather than variations in metabolite concentrations given the short repetition time and long echo time values used, our findings point to thalamic dysfunction, corroborating prior evidence.
Subject: Adolescent
Adult
Aged
Aspartic Acid
Case-control Studies
Creatine
Deuterium
Dipeptides
Female
Glycerylphosphorylcholine
Humans
Huntington Disease
Magnetic Resonance Spectroscopy
Male
Middle Aged
Motor Activity
Phosphocreatine
Phosphorylcholine
Thalamic Diseases
Thalamus
Trinucleotide Repeats
Young Adult
Rights: aberto
Identifier DOI: 10.1590/1414-431X20132332
Address: http://www.ncbi.nlm.nih.gov/pubmed/23969973
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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