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http://repositorio.unicamp.br/jspui/handle/REPOSIP/200762
Type: | Artigo de periódico |
Title: | Etiologic And Diagnostic Evaluation: Algorithm For Severe To Profound Sensorineural Hearing Loss In Brazil. |
Author: | Ramos, Priscila Zonzini de Moraes, Vanessa Cristine Sousa Svidnicki, Maria Carolina Costa Melo Soki, Marcelo Naoki Castilho, Arthur Menino Sartorato, Edi Lúcia |
Abstract: | Evaluation of the effectiveness of imaging and genetic testing, and establishment of a cost-effective diagnostic protocol for the etiologic diagnosis of sensorineural hearing loss (SNHL) in Brazil. Prospective cohort study. Analysis of 100 unrelated Brazilian patients with severe to profound bilateral SNHL submitted to cochlear implant (CI) between 2002 and 2010 at the University of Campinas hospital. The study was based upon three groups: individuals with congenital, progressive, and sudden SNHL. After the diagnostic investigation, the number of cases with unknown etiology was reduced from 72 to 42 (a 42% reduction); 25% of cases were due to environmental factors, 19% to genetic causes, and 14% to inner-ear abnormalities or other clinical features. The genetic and imaging findings contributed to the diagnosis of SNHL in 19% and 20% of the cases analysed, respectively. Molecular testing mainly contributed to the diagnosis of patients with congenital SNHL, while the contribution of radiologic examination was higher for individuals with progressive or sudden SNHL. A sequential diagnostic protocol was proposed based on these data. The proposed diagnostic workup algorithm could provide better optimization of etiologic diagnosis, as well as reduced costs, compared to a simultaneous testing approach. |
Subject: | Adolescent Adult Aged Algorithms Brazil Child Child, Preschool Cochlear Implantation Cost-benefit Analysis Dna Mutational Analysis Diagnostic Imaging Female Genetic Predisposition To Disease Genetic Testing Health Care Costs Hearing Loss, Sensorineural Hearing Tests Hospitals, University Humans Magnetic Resonance Imaging Male Middle Aged Mutation Predictive Value Of Tests Prognosis Prospective Studies Risk Factors Severity Of Illness Index Tomography, X-ray Computed Young Adult |
Citation: | International Journal Of Audiology. v. 52, n. 11, p. 746-52, 2013-Nov. |
Rights: | fechado |
Identifier DOI: | 10.3109/14992027.2013.817689 |
Address: | http://www.ncbi.nlm.nih.gov/pubmed/23909750 |
Date Issue: | 2013 |
Appears in Collections: | Unicamp - Artigos e Outros Documentos |
Files in This Item:
File | Size | Format | |
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pmed_23909750.pdf | 129.82 kB | Adobe PDF | View/Open |
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