Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Etiologic And Diagnostic Evaluation: Algorithm For Severe To Profound Sensorineural Hearing Loss In Brazil.
Author: Ramos, Priscila Zonzini
de Moraes, Vanessa Cristine Sousa
Svidnicki, Maria Carolina Costa Melo
Soki, Marcelo Naoki
Castilho, Arthur Menino
Sartorato, Edi Lúcia
Abstract: Evaluation of the effectiveness of imaging and genetic testing, and establishment of a cost-effective diagnostic protocol for the etiologic diagnosis of sensorineural hearing loss (SNHL) in Brazil. Prospective cohort study. Analysis of 100 unrelated Brazilian patients with severe to profound bilateral SNHL submitted to cochlear implant (CI) between 2002 and 2010 at the University of Campinas hospital. The study was based upon three groups: individuals with congenital, progressive, and sudden SNHL. After the diagnostic investigation, the number of cases with unknown etiology was reduced from 72 to 42 (a 42% reduction); 25% of cases were due to environmental factors, 19% to genetic causes, and 14% to inner-ear abnormalities or other clinical features. The genetic and imaging findings contributed to the diagnosis of SNHL in 19% and 20% of the cases analysed, respectively. Molecular testing mainly contributed to the diagnosis of patients with congenital SNHL, while the contribution of radiologic examination was higher for individuals with progressive or sudden SNHL. A sequential diagnostic protocol was proposed based on these data. The proposed diagnostic workup algorithm could provide better optimization of etiologic diagnosis, as well as reduced costs, compared to a simultaneous testing approach.
Subject: Adolescent
Child, Preschool
Cochlear Implantation
Cost-benefit Analysis
Dna Mutational Analysis
Diagnostic Imaging
Genetic Predisposition To Disease
Genetic Testing
Health Care Costs
Hearing Loss, Sensorineural
Hearing Tests
Hospitals, University
Magnetic Resonance Imaging
Middle Aged
Predictive Value Of Tests
Prospective Studies
Risk Factors
Severity Of Illness Index
Tomography, X-ray Computed
Young Adult
Citation: International Journal Of Audiology. v. 52, n. 11, p. 746-52, 2013-Nov.
Rights: fechado
Identifier DOI: 10.3109/14992027.2013.817689
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_23909750.pdf129.82 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.