Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200749
Type: Artigo de periódico
Title: Chloroquine: Modes Of Action Of An Undervalued Drug.
Author: Thomé, Rodolfo
Lopes, Stefanie Costa Pinto
Costa, Fabio Trindade Maranhão
Verinaud, Liana
Abstract: For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such as rheumatoid arthritis and transplantation procedures, presenting intriguing and promising results. In this review, we discuss recent findings and CQ mechanisms of action vis-à-vis its use as a broad adjunct therapy.
Subject: Anti-inflammatory Agents
Arthritis, Rheumatoid
Chloroquine
Drug Resistance, Bacterial
Eye
Humans
Immunosuppressive Agents
Lysosomes
Malaria
Plasmodium
Transplantation
Transplantation Immunology
Autoimmunity
Chloroquine
Malaria
Transplantation
Rights: fechado
Identifier DOI: 10.1016/j.imlet.2013.07.004
Address: http://www.ncbi.nlm.nih.gov/pubmed/23891850
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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