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Type: Artigo de periódico
Title: Characterization Of The Immune Response In Human Paracoccidioidomycosis.
Author: de Castro, Lívia Furquim
Ferreira, Maria Carolina
da Silva, Rosiane Maria
Blotta, Maria Heloisa de Souza Lima
Longhi, Larissa Nara Alegrini
Mamoni, Ronei Luciano
Abstract: Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis that presents two main clinical forms: the adult form (AF) and the juvenile form (JF); and an asymptomatic form denominated PCM-infection (PI). These forms of PCM are related to the immune response developed after infection, which has been associated with Th1 and Th2 responses. However, some PCM characteristics cannot be explained by this balance. In this study we aimed to complement the characterization of the immune response in PCM, including the newly described T cells subpopulations (Th17, Th9 and Th22). We analyzed the expression of cytokines and transcription factors characteristics of these different subpopulations of CD4(+) T cells in PBMCs from PCM patients and a PI group. The results showed that the PI group presented a predominant Th1 response; that JF patients were characterized by a mixed Th2/Th9 response; and AF patients were characterized by a predominant Th17/Th22 response, as well as substantial participation of Th1 cells. These results contribute to the existing knowledge on the immune responses associated with resistance or susceptibility to the P. brasiliensis infection, and thus could lead to the development of new strategies for patient management.
Subject: Analysis Of Variance
Case-control Studies
Cohort Studies
T-lymphocytes, Helper-inducer
Th1 Cells
Th17 Cells
Th2 Cells
Adaptative Immune Response
Rights: fechado
Identifier DOI: 10.1016/j.jinf.2013.07.019
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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