Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Inflammatory Process Induced By Carrageenan In Adjacent Tissue Triggers The Acute Inflammation In Deep Digital Flexor Tendon Of Rats.
Author: Vieira, Cristiano Pedrozo
De Aro, Andrea Aparecida
Da Ré Guerra, Flávia
De Oliveira, Letícia Prado
De Almeida, Marcos Dos Santos
Pimentel, Edson Rosa
Abstract: Tendinopathy is a pathology found mainly in the rotator cuff, patellar, Achilles and flexor tendons. Tendinopathy is a significant impediment to performance in athletes and in workers in the labor market. Some studies have indicated that inflammation in adjacent tissues may affect the rotator cuff and Achilles tendon. In this study alterations were verified in the extracellular matrix (ECM) of the deep digital flexor tendon after two periods (12 and 24 hr) of induction inflammation in rat paw. Wistar rats were divided into three groups: those that received injection of 1% carrageenan; those that received 0.9% NaCl; and those that received no application. The tendon was divided into distal (d), proximal (p), and intermediate (i) regions. Biochemical analyses were performed and included non-collagenous proteins (NCP), glycosaminoglycans (GAGs), hydroxyproline (HoPro) and metalloproteinases 2 and 9. Tissue sections were stained with toluidine blue, hematoxylin-eosin, and Ponceau SS and observed under polarization microscopy. Remarkable results were detected that included the presence of MMP-9, degradation of NCP and GAG and the presence of cellular infiltrate closer to digits in d region. The different concentrations of HoPro, as well as alterations in the organization of the collagen fibers showed the collagenous matrix undergoing some alterations. The results indicated that the induced inflammation in rat paw exhibited characteristics similar to the typical acute inflammatory process observed in tendons.
Subject: Animals
Disease Models, Animal
Extracellular Matrix
Matrix Metalloproteinase 9
Rats, Wistar
Time Factors
Acute Inflammation
Extracellular Matrix
Citation: Anatomical Record (hoboken, N.j. : 2007). v. 296, n. 8, p. 1187-95, 2013-Aug.
Rights: fechado
Identifier DOI: 10.1002/ar.22729
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_23775880.pdf399.52 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.