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Type: Artigo de periódico
Title: Zoledronic Acid Decreases Gene Expression Of Vascular Endothelial Growth Factor And Basic Fibroblast Growth Factor By Human Epithelial Cells.
Author: Basso, Fernanda G
Turrioni, Ana Paula S
Hebling, Josimeri
de Souza Costa, Carlos Alberto
Abstract: Delayed wound healing in patients taking bisphosphonates could result from decreased expression of growth factors, which are directly related to cell proliferation and migration. In this study, we evaluated the gene expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) by epithelial cells exposed to zoledronic acid 5 μmol for 48 h using real-time polymerase chain reaction. The gene expression of VEGF and bFGF by epithelial cells exposed to zoledronic acid decreased by 34% and 51%, respectively (p=0.0001 and p=0.0001). We conclude that zoledronic acid can decrease the expression of growth factors by epithelial cells.
Subject: Bisphosphonates
Epithelial Cells
Tissue Healing
Citation: The British Journal Of Oral & Maxillofacial Surgery. v. 51, n. 8, p. 971-3, 2013-Dec.
Rights: fechado
Identifier DOI: 10.1016/j.bjoms.2013.05.010
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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