Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200673
Type: Artigo de periódico
Title: Skin Vasodilation And Analgesic Effect Of A Topical Nitric Oxide-releasing Hydrogel.
Author: Vercelino, Rafael
Cunha, Thiago Mattar
Ferreira, Elisa Silva
Cunha, Fernando Q
Ferreira, Sérgio H
de Oliveira, Marcelo G
Abstract: New approaches based on topical treatments are needed for treating pain and impaired dermal blood flow. We used a topical Pluronic F127 hydrogel containing S-nitrosoglutathione (GSNO) as a prodrug to generate free NO, an effector molecule that exerts both dermal vasodilation and antinociceptive effects. GSNO-containing hydrogels underwent gelation above 12 °C and released free NO at rates that were directly dependent on the GSNO concentration in the range of 50-150 mM. The topical application of this material led to dose-response dermal vasodilation in healthy volunteers and to a reduction of up to 50 % of the hypernociception intensity in Wistar rats that were subjected to inflammatory pain. Mechanistic investigations indicated that the antinociceptive effect of the topical F127/GSNO hydrogels is produced by the local activation of the cGMP/PKG/KATP channel-signaling pathway, which was stimulated by the free NO that diffused through the skin. These results expand the scope of the biomedical applications of this material and may represent a new approach for the topical treatment of inflammatory pain.
Subject: Administration, Topical
Adult
Analgesics
Animals
Calorimetry, Differential Scanning
Dose-response Relationship, Drug
Female
Humans
Hydrogels
Male
Nitric Oxide
Rats
Rats, Wistar
Skin
Vasodilation
Vasodilator Agents
Young Adult
Citation: Journal Of Materials Science. Materials In Medicine. v. 24, n. 9, p. 2157-69, 2013-Sep.
Rights: fechado
Identifier DOI: 10.1007/s10856-013-4973-7
Address: http://www.ncbi.nlm.nih.gov/pubmed/23756965
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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