Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Diffuse Optical Characterization Of An Exercising Patient Group With Peripheral Artery Disease.
Author: Mesquita, Rickson C
Putt, Mary
Chandra, Malavika
Yu, Guoqiang
Xing, Xiaoman
Han, Sung Wan
Lech, Gwen
Shang, Yu
Durduran, Turgut
Zhou, Chao
Yodh, Arjun G
Mohler, Emile R
Abstract: Peripheral artery disease (PAD) is a common condition with high morbidity. While measurement of tissue oxygen saturation (S(t)O(2)) has been demonstrated, this is the first study to assess both S(t)O(2) and relative blood flow (rBF) in the extremities of PAD patients. Diffuse optics is employed to measure hemodynamic response to treadmill and pedal exercises in 31 healthy controls and 26 patients. For S(t)O(2), mild and moderate/severe PAD groups show pronounced differences compared with controls. Pre-exercise mean S(t)O(2) is lower in PAD groups by 9.3% to 10.6% compared with means of 63.5% to 66.2% in controls. For pedal, relative rate of return of S(t)O(2) to baseline is more rapid in controls (p < 0.05). Patterns of rBF also differ among groups. After both exercises, rBF tend to occur at depressed levels among severe PAD patients compared with healthy (p < 0.05); post-treadmill, rBF tend to occur at elevated levels among healthy compared with severe PAD patients (p < 0.05). Additionally, relative rate of return to baseline S(t)O(2) is more rapid among subjects with reduced levels of depression in rBF (p = 0.041), even after adjustment for ankle brachial index. This suggests a physiologic connection between rBF and oxygenation that can be measured using diffuse optics, and potentially employed as an evaluative tool in further studies.
Subject: Aged
Ankle Brachial Index
Case-control Studies
Middle Aged
Peripheral Vascular Diseases
Regional Blood Flow
Spectroscopy, Near-infrared
Spectrum Analysis
Statistics, Nonparametric
Rights: aberto
Identifier DOI: 10.1117/1.JBO.18.5.057007
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_23708193.pdf1.11 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.