Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200619
Type: Artigo de periódico
Title: Clinical Utility Of Kap-1 Expression In Thyroid Lesions.
Author: Martins, Mariana Bonjiorno
Marcello, Marjory Alana
Morari, Elaine Cristina
Cunha, Lucas Leite
Soares, Fernando Augusto
Vassallo, José
Ward, Laura Sterian
Abstract: Although there are evidences of the involvement of KAP-1 in other tumors, data on differentiated thyroid carcinomas (DTC) are still lacking. We aimed to evaluate KAP-1 clinical utility in the diagnosis and prognosis of DTC. We used both visual immunohistochemistry and a semiquantitative analysis to evaluate KAP-1 expression in 230 thyroid carcinomas and 131 noncancerous thyroid nodules. There were 43 follicular carcinomas (FC) and 187 papillary thyroid carcinomas (PTC), including 130 classic (CPTC), 4 tall cells (TCPTC), and 53 follicular variants (FVPTC). Patients were followed up for 53.8 ± 41 months. They were classified as free-of-disease (142 cases) or poor outcome (25 cases--10 deaths), according to their serum Tg levels and image evidences. KAP-1 was identified in 78 % PTC, 75 % TCPTC, 74 % FC, 72 % FVPTC, 55 % FA, 44 % hyperplasia, and 11 % normal thyroid tissues. A ROC analysis identified malignant nodules with 69 % sensitivity and 75 % specificity, using a cutoff of 73.19. In addition to distinguishing benign from malignant thyroid tissues (p < 0.0001), KAP-1 expression differentiated CPTC from nodular hyperplasia (p < 0.0001), CPTC from FA (p = 0.0028), FVPTC from hyperplasia (p = 0.0039), and FC from hyperplasia (p = 0.0025). Furthermore, KAP-1 was more expressed in larger tumors (>4 cm; p = 0.0038) and in individuals who presented recurrences/metastases (p = 0.0130). We suggest that KAP-1 may help diagnose thyroid nodules, characterize follicular-patterned thyroid lesions, and identify individuals with poor prognosis.
Subject: Adenocarcinoma, Papillary
Adolescent
Adult
Aged
Aged, 80 And Over
Carcinoma, Papillary, Follicular
Female
Humans
Hyperplasia
Male
Middle Aged
Prognosis
Repressor Proteins
Survival Rate
Thyroid Gland
Thyroid Neoplasms
Thyroid Nodule
Tumor Markers, Biological
Young Adult
Rights: fechado
Identifier DOI: 10.1007/s12022-013-9245-z
Address: http://www.ncbi.nlm.nih.gov/pubmed/23645532
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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