Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200598
Type: Artigo de periódico
Title: Anti-inflammatory And Antimicrobial Evaluation Of Neovestitol And Vestitol Isolated From Brazilian Red Propolis.
Author: Bueno-Silva, Bruno
Alencar, Severino M
Koo, Hyun
Ikegaki, Masaharu
Silva, Gil V J
Napimoga, Marcelo H
Rosalen, Pedro L
Abstract: The objective of this study was to evaluate anti-inflammatory and antimicrobial activities of neovestitol and vestitol isolated from Brazilian red propolis (BRP). BRP ethanolic extract (EEP), neovestitol, and vestitol were evaluated by anti-inflammatory properties using a neutrophil migration assay. The antimicrobial activity was evaluated by minimal inhibitory and bactericidal concentrations (MIC and MBC) against Streptococcus mutans , Streptococcus sobrinus , Staphylococcus aureus , and Actinomyces naeslundii . Neovestitol, vestitol, and EEP inhibited neutrophil migration at a dose of 10 mg/kg. Regarding antimicrobial activity, neovestitol showed MICs ranging from <6.25 to 25-50 μg/mL and MBCs ranging from 25-50 to 50-100 μg/mL, while vestitol showed MICs ranging from 25-50 to 50-100 μg/mL and MBCs ranging from 25-50 to 50-100 μg/mL. Both isoflavonoids neovestitol and vestitol are consistent bioactive compounds displaying anti-inflammatory and antimicrobial activities that can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries.
Subject: Actinomyces
Animals
Anti-infective Agents
Anti-inflammatory Agents
Brazil
Flavonoids
Inflammation
Male
Mice
Mice, Inbred Balb C
Microbial Sensitivity Tests
Propolis
Staphylococcus Aureus
Streptococcus Mutans
Streptococcus Sobrinus
Rights: fechado
Identifier DOI: 10.1021/jf305468f
Address: http://www.ncbi.nlm.nih.gov/pubmed/23607483
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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