Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200590
Type: Artigo de periódico
Title: Melatonin And Ethanol Intake Exert Opposite Effects On Circulating Estradiol And Progesterone And Differentially Regulate Sex Steroid Receptors In The Ovaries, Oviducts, And Uteri Of Adult Rats.
Author: Chuffa, Luiz Gustavo A
Seiva, Fábio R F
Fávaro, Wagner José
Amorim, João Paulo A
Teixeira, Giovana R
Mendes, Leonardo O
Fioruci-Fontanelli, Beatriz A
Pinheiro, Patricia Fernanda F
Martinez, Marcelo
Martinez, Francisco Eduardo
Abstract: Chronic ethanol intake is associated with sex hormone disturbances, and it is well known that melatonin plays a key role in regulating several reproductive processes. We report the effects of ethanol intake and melatonin treatment (at doses of 100 μg/100 g BW/day) on sex hormones and steroid receptors in the ovaries, oviducts and uteri of ethanol-preferring rats. After 150 days of treatment, animals were euthanized, and tissue samples were harvested to evaluate androgen, estrogen, progesterone and melatonin receptor subunits (AR, ER-α and ER-β, PRA, PRB and MT1R, respectively). Melatonin decreased estradiol (E2) and increased progesterone (P4) and 6-sulfatoxymelatonin (6-STM), while an ethanol-melatonin combination reduced both P4 and E2. Ovarian AR was not influenced by either treatment, and oviduct AR was reduced after ethanol-melatonin combination. Oviduct ER-α, ER-β and uterine ER-β were down-regulated by either ethanol or melatonin. Conversely, ovarian PRA and PRB were positively regulated by ethanol and ethanol-melatonin combination, whereas PRA was down-regulated in the uterus and oviduct after ethanol consumption. MT1R was increased in ovaries and uteri of melatonin-treated rats. Ethanol and melatonin exert opposite effects on E2 and P4, and they differentially regulate the expression of sex steroid receptors in female reproductive tissues.
Subject: Alcoholism
Animals
Estradiol
Ethanol
Female
Melatonin
Ovary
Oviducts
Progesterone
Rats
Receptors, Steroid
Uterus
Rights: fechado
Identifier DOI: 10.1016/j.reprotox.2013.04.001
Address: http://www.ncbi.nlm.nih.gov/pubmed/23591044
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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