Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200578
Type: Artigo de periódico
Title: Simvastatin Attenuates Neutrophil Recruitment In One-lung Ventilation Model In Rats.
Author: Leite, Camila Ferreira
Marangoni, Fábio André
Camargo, Enilton Aparecido
Braga, Angélica de Fátima de Assunção
Toro, Ivan Felizardo Contrera
Antunes, Edson
Landucci, Elen Cristina Tiezem
Mussi, Ricardo Kalaf
Abstract: To investigate the anti-inflammatory effects of simvastatin in rats undergoing one-lung ventilation (OLV) followed by lung re-expansion. Male Wistar rats (n=30) were submitted to 1-h OLV followed by 1-h lung re-expansion. Treated group received simvastatin (40 mg/kg for 21 days) previous to OLV protocol. Control group received no treatment or surgical/ventilation interventions. Measurements of pulmonary myeloperoxidase (MPO) activity, pulmonary protein extravasation, and serum levels of cytokines and C-reactive protein (CRP) were performed. OLV significantly increased the MPO activity in the collapsed and continuously ventilated lungs (31% and 52% increase, respectively) compared with control (p<0.05). Treatment with simvastatin significantly reduced the MPO activity in the continuously ventilated lung but had no effect on lung edema after OLV. The serum IL-6 and CRP levels were markedly higher in OLV group, but simvastatin treatment failed to affect the production of these inflammatory markers. Serum levels of IL-1β, TNF-α and IL-10 remained below the detection limit in all groups. In an experimental one-lung ventilation model pre-operative treatment with simvastatin reduces remote neutrophil infiltration in the continuously ventilated lung. Our findings suggest that simvastatin may be of therapeutic value in OLV-induced pulmonary inflammation deserving clinical investigations.
Subject: Animals
Anti-inflammatory Agents
C-reactive Protein
Cytokines
Hydroxymethylglutaryl-coa Reductase Inhibitors
Lung
Male
Models, Animal
Neutrophil Infiltration
One-lung Ventilation
Peroxidase
Random Allocation
Rats
Rats, Wistar
Reproducibility Of Results
Simvastatin
Thoracic Surgical Procedures
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/23568231
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_23568231.pdf346.33 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.