Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200572
Type: Artigo de periódico
Title: A Dipeptide And An Amino Acid Present In Whey Protein Hydrolysate Increase Translocation Of Glut-4 To The Plasma Membrane In Wistar Rats.
Author: Morato, P N
Lollo, P C B
Moura, C S
Batista, T M
Carneiro, E M
Amaya-Farfan, J
Abstract: Whey protein hydrolysate (WPH) is capable of increasing muscle glycogen reserves and of concentrating the glucose transporter in the plasma membrane (PM). The objective of this study was to determine which WPH components could modulate translocation of the glucose transporter GLUT-4 to the PM of animal skeletal muscle. Forty-nine animals were divided into 7 groups (n=7) and received by oral gavage 30% glucose plus 0.55 g/kg body mass of the following WPH components: (a) control; (b) WPH; (c) L-isoleucine; (d) L-leucine; (e) L-leucine plus L-isoleucine; (f) L-isoleucyl-L-leucine dipeptide; (g) L-leucyl-L-isoleucine dipeptide. After receiving these solutions, the animals were sacrificed and the GLUT-4 analysed by western blot. Additionally, glycogen, glycaemia, insulin and free amino acids were also determined by standard methods. Of the WPH components tested, the amino acid L-isoleucine and the peptide L-leucyl-L-isoleucine showed greater efficiency in translocating GLUT-4 to the PM and of increasing glucose capture by skeletal muscle.
Subject: Amino Acids
Animals
Cell Membrane
Dipeptides
Glucose
Glucose Transporter Type 4
Glycogen
Male
Milk Proteins
Muscle, Skeletal
Protein Hydrolysates
Protein Transport
Rats
Rats, Wistar
Rights: fechado
Identifier DOI: 10.1016/j.foodchem.2012.12.062
Address: http://www.ncbi.nlm.nih.gov/pubmed/23561181
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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