Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200564
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleImpregnation Of Implantable Polypropylene Mesh With S-nitrosoglutathione-loaded Poly(vinyl Alcohol).pt_BR
dc.contributor.authorPrudente, Alessandropt_BR
dc.contributor.authorRiccetto, Cássio Luís Zanettinipt_BR
dc.contributor.authorSimões, Maíra Martins de Souza Godoypt_BR
dc.contributor.authorPires, Bruno Morandipt_BR
dc.contributor.authorde Oliveira, Marcelo Ganzarollipt_BR
unicamp.authorAlessandro Prudente, Urology Division, Department of Surgery, Faculty of Medical Science, University of Campinas-UNICAMP, 13083-887 Campinas, São Paulo, Brazil.pt_BR
unicamp.author.externalCássio Luís Zanettini Riccetto,pt
unicamp.author.externalMaíra Martins de Souza Godoy Simões,pt
unicamp.author.externalBruno Morandi Pires,pt
unicamp.author.externalMarcelo Ganzarolli de Oliveira,pt
dc.subjectAbdominal Wallpt_BR
dc.subjectAnimalspt_BR
dc.subjectBiocompatible Materialspt_BR
dc.subjectFemalept_BR
dc.subjectMicroscopy, Electron, Scanningpt_BR
dc.subjectNeovascularization, Physiologicpt_BR
dc.subjectNitric Oxidept_BR
dc.subjectNitric Oxide Donorspt_BR
dc.subjectPolypropylenespt_BR
dc.subjectPolyvinyl Alcoholpt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectS-nitrosoglutathionept_BR
dc.subjectSurgical Meshpt_BR
dc.subjectWettabilitypt_BR
dc.description.abstractClinical complications of implantable polypropylene (PP) meshes used to repair urinary incontinence and vaginal prolapse may be associated with their low surface energy and consequent poor tissue integration. For improving tissue integration, we impregnated monofilament PP meshes with physically crosslinked poly(vinyl alcohol) (PVA), resulting in PVA deposits tightly attached inside the knot spaces of the PP knit. While preserving the mesh porosity, the PVA deposits acted as an array of hydrophilic regions leading to a great increase in the overall mesh wettability, reflected by a contact angle decrease from 111 to ca. 66°. The PVA deposits were also used as reservoirs for the local release of S-nitrosoglutathione (GSNO), a nitric oxide (NO) donor. Plain and impregnated PP meshes (1.0cm×1.0cm) were implanted in the subcutaneous tissue of 21 adult female Wistar rats. Histological analysis of the abdominal wall 21 days after the surgeries revealed lower edema and greater angiogenesis while a marked decrement of NOx concentration in the tissue surrounding the impregnated meshes was observed after 2 days. These results indicate that PVA and PVA/GSNO impregnation might be a new strategy for decreasing the frequency of mesh extrusion after PP mesh implants.en
dc.relation.ispartofColloids And Surfaces. B, Biointerfacespt_BR
dc.relation.ispartofabbreviationColloids Surf B Biointerfacespt_BR
dc.date.issued2013-Augpt_BR
dc.identifier.citationColloids And Surfaces. B, Biointerfaces. v. 108, p. 178-84, 2013-Aug.pt_BR
dc.language.isoengpt_BR
dc.description.volume108pt_BR
dc.description.firstpage178-84pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2013 Elsevier B.V. All rights reserved.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1873-4367pt_BR
dc.identifier.doi10.1016/j.colsurfb.2013.02.018pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23545088pt_BR
dc.date.available2015-11-27T13:31:34Z-
dc.date.accessioned2015-11-27T13:31:34Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:31:34Z (GMT). No. of bitstreams: 1 pmed_23545088.pdf: 1384453 bytes, checksum: d260bb7b332bf52522a3938ef9298b94 (MD5) Previous issue date: 2013en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200564-
dc.identifier.idPubmed23545088pt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_23545088.pdf1.35 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.