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Type: Artigo de periódico
Title: The Impact Of Cystic Fibrosis On The Immunologic Profile Of Pediatric Patients.
Author: Bernardi, Daniela M
Ribeiro, Antonio F
Mazzola, Tais N
Vilela, Maria M S
Sgarbieri, Valdemiro C
Abstract: To compare the immunologic state of 44 pediatric patients with cystic fibrosis (CF) with a control group consisting of 16 healthy individuals. CF patients aged 3 to 12 years with moderate to good clinical score were selected for the study. Erythrocytic glutathione, production of reactive oxygen species, cytokines (TNF-a, IFN-g, IL-8, IL-6, IL-10) in peripheral blood mononuclear cells cultures under spontaneous and BCG- or PHA-stimulated conditions, serum concentrations of TGF-b2, IgA, IgG, IgM, IgE, and salivary IgA were evaluated. The spontaneous production of TNF-a, IL-6, and IL-10, the PHA-stimulated production of IL-6, and the serum TGF-b2, IgA, and IgG were increased in samples from CF patients. Healthy subjects had a higher production of TNF-a in response to BCG. Although CF patients appeared clinically stable, the results of their peripheral blood examinations demonstrated an impact on the immune system.
Subject: Case-control Studies
Cell Culture Techniques
Child, Preschool
Cross-sectional Studies
Cystic Fibrosis
Enzyme-linked Immunosorbent Assay
Inflammation Mediators
Leukocytes, Mononuclear
Monitoring, Immunologic
Reactive Oxygen Species
Transforming Growth Factor Beta2
Citation: Jornal De Pediatria. v. 89, n. 1, p. 40-7
Rights: aberto
Identifier DOI: 10.1016/j.jped.2013.02.007
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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