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Type: Artigo de periódico
Title: Carcinoma Ex-pleomorphic Adenoma Of Upper Lip Showing Copy Number Loss Of Tumor Suppressor Genes.
Author: Mariano, Fernanda Viviane
Rincon, Daniel
Gondak, Rogério Oliveira
Jorge, Rogério
Lopes, Márcio Ajudarte
Altemani, Albina
de Almeida, Oslei Paes
Kowalski, Luiz Paulo
Abstract: Carcinoma ex-pleomorphic adenoma (CXPA) is a malignant salivary gland tumor that arises rarely in the minor salivary glands. Although the etiology of CXPA remains unclear, the role of some tumor suppressor genes and oncogenes in CXPA is documented; however, other genes still need to be studied. An uncommon case of CXPA involving the upper lip is presented, which was analyzed by a panel of tumor suppressor genes by multiplex ligation-dependent probe amplification. The genes investigated in this study, a loss of copy number was detected for CASP8, CD44, CDH1, DAPK1, ESR1, RASSF1, and TP73. Immunohistochemical reactions for the validation of some of these results showed negativity for CD44, RASSF1, and p73. A loss of copy number of the genes CD44, RASSF1, and TP73 may contribute to the carcinogenesis of CXPAs.
Subject: Adenocarcinoma
Adenoma, Pleomorphic
Dna Copy Number Variations
Genes, Tumor Suppressor
Multiplex Polymerase Chain Reaction
Salivary Gland Neoplasms
Salivary Glands, Minor
Citation: Oral Surgery, Oral Medicine, Oral Pathology And Oral Radiology. v. 116, n. 1, p. 69-74, 2013-Jul.
Rights: fechado
Identifier DOI: 10.1016/j.oooo.2012.12.015
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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