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Type: Artigo de periódico
Title: N-acetylcysteine Treatment Reduces Tnf-α Levels And Myonecrosis In Diaphragm Muscle Of Mdx Mice.
Author: de Senzi Moraes Pinto, Rafael
Ferretti, Renato
Moraes, Luis Henrique Rapucci
Neto, Humberto Santo
Marques, Maria Julia
Minatel, Elaine
Abstract: Duchenne muscular dystrophy (DMD) is a genetic muscle disease caused by the absence of dystrophin. An established animal model of DMD is the mdx mouse, which is unable to express dystrophin. Inflammation, particularly the proinflammatory cytokine tumor necrosis factor alpha (TNF-α), strongly contributes to necrosis in the dystrophin-deficient fibers of the mdx mice and in DMD. In this study we investigated whether the antioxidant N-acetylcysteine (NAC) decreases TNF-α levels and protects the diaphragm muscle of mdx mice against necrosis. Mdx mice (14 days old) received daily intraperitoneal injections of NAC for 14 days, followed by removal of the diaphragm muscle. Control mdx mice were injected with saline. NAC reduced TNF-α and 4-HNE-protein adducts levels, inflammation, creatine kinase levels, and myonecrosis in diaphragm muscle. NAC may be used as a complementary treatment for dystrophinopathies. However, clinical trials are needed to determine the appropriate dose for patients with Duchenne muscular dystrophy.
Subject: Acetylcysteine
Mice, Inbred C57bl
Mice, Inbred Mdx
Muscle, Skeletal
Tumor Necrosis Factor-alpha
Citation: Clinical Nutrition (edinburgh, Scotland). v. 32, n. 3, p. 472-5, 2013-Jun.
Rights: fechado
Identifier DOI: 10.1016/j.clnu.2012.06.001
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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