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Type: Artigo de periódico
Title: Il10 Inversely Correlates With The Percentage Of Cd8⁺ Cells In Mds Patients.
Author: Lopes, Matheus Rodrigues
Traina, Fabiola
Campos, Paula de Melo
Pereira, João Kleber Novais
Machado-Neto, João Agostinho
Machado, Helymar da Costa
Gilli, Simone Cristina Olenscki
Saad, Sara Teresinha Olalla
Favaro, Patricia
Abstract: The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS.
Subject: Adult
Aged, 80 And Over
Cd4-positive T-lymphocytes
Cd8-positive T-lymphocytes
Ctla-4 Antigen
Forkhead Transcription Factors
Gene Expression Regulation
Lymphocyte Count
Middle Aged
Myelodysplastic Syndromes
Risk Factors
Transforming Growth Factor Beta1
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2013.01.019
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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