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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt
dc.typeArtigo de periódicopt
dc.titleAn Appraisal Of The Chemical And Thermal Stability Of Silica Based Reversed-phase Liquid Chromatographic Stationary Phases Employed Within The Pharmaceutical Environment.pt
dc.contributor.authorBorges, Endler Mpt
dc.contributor.authorEuerby, Melvin Rpt
unicamp.authorEndler M Borges, Universidade Estadual de Campinas, Instituto de Química, Rua Monteiro Lobato, Cidade Universitária Zeferino Vaz, Distrito de Barão Geraldo, Campinas, SP, Brazil. marcelborgesb@gmail.compt
unicamp.author.externalMelvin R Euerby,pt
dc.subjectChromatography, Reverse-phasept
dc.subjectHydrogen-ion Concentrationpt
dc.subjectPharmaceutical Preparationspt
dc.subjectSilicon Dioxidept
dc.subjectTemperaturept
dc.description.abstractMobile phase pH and temperature are major factors in determining retention, selectivity and chromatographic performance of ionizable compounds. This imposes a requirement that stationary phases must ideally be stable in both acidic and basic conditions coupled with good thermal stability, in order to be able to chromatograph these compounds in either their ionized or ion-suppressed modes. The development of a range of new high and/or low pH stable silica based RPLC stationary phases (including sub-2 μm fully porous and sub-3 μm fused core-shell materials), which are specially designed for the analysis of ionizable compounds and their chemical and thermal stability is reviewed. The ability to utilize both pH and temperature as selectivity variables allows the chromatographer to exploit a much wider method development design space including previously prohibited alkaline conditions. This greatly increases the probability of satisfying the desired chromatographic selectivity and performance criteria.en
dc.relation.ispartofJournal Of Pharmaceutical And Biomedical Analysisen
dc.relation.ispartofabbreviationJ Pharm Biomed Analpt
dc.date.issued2013-Aprpt
dc.identifier.citationJournal Of Pharmaceutical And Biomedical Analysis. v. 77, p. 100-15, 2013-Apr.pt
dc.language.isoengpt
dc.description.volume77pt
dc.description.initialpage100-15pt
dc.rightsfechadopt
dc.rights.holderCopyright © 2013 Elsevier B.V. All rights reserved.pt
dc.sourcePubMedpt
dc.identifier.issn1873-264Xpt
dc.identifier.doi10.1016/j.jpba.2013.01.013pt
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23411003en
dc.date.available2015-11-27T13:31:22Z-
dc.date.accessioned2015-11-27T13:31:22Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:31:22Z (GMT). No. of bitstreams: 1 pmed_23411003.pdf: 1110406 bytes, checksum: 56200d6e76ab8c95736f1d3e44f9e3a1 (MD5) Previous issue date: 2013en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200491-
dc.identifier.idPubmed23411003pt
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