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Type: Artigo de periódico
Title: Advantage Of Guaraná (paullinia Cupana Mart.) Supplementation On Cadmium-induced Damages In Testis Of Adult Wistar Rats.
Author: Leite, Rodrigo P
Predes, Fabrícia S
Monteiro, Juliana C
Freitas, Karine M
Wada, Ronaldo S
Dolder, Heidi
Abstract: Paullinia cupana is an Amazonian bush whose seeds have long been used in folk medicine. However, most of the therapeutic properties attributed to this plant are broad and nonspecific, although an antioxidant activity has been reported.  On the other hand, cadmium is a heavy metal known for increasing free radicals, hence resulting in cellular oxidative damages. This study was designed to evaluate whether Paullinia cupana is able to reduce cadmium-induced morphological impairment in Wistar rat testis. Adult male Wistar rats 110 days old were ip injected with cadmium (1.15 mg/kg BW [body weight]) and subsequently treated with P. cupana during 56 days.  Furthermore, groups receiving either P. cupana extract or cadmium are mentioned. After the treatment period, testis samples were subjected to histological and stereological analyses. Moderate to severe testicular impairments were shown by the animals exposed to cadmium. However, the animals supplemented with P. cupana after cadmium exposure showed a significant decrease in the proportion of damaged seminiferous tubules. Also, P. cupana supplementation was effective in maintaining the number of Leydig cells per testis in the animals exposed to cadmium. In conclusion, P. cupana supplementation was partially efficient in preventing cadmium from damaging the testis of adult Wistar rats.
Subject: Analysis Of Variance
Body Weight
Leydig Cells
Plant Extracts
Protective Agents
Rats, Wistar
Toxicity Tests
Citation: Toxicologic Pathology. v. 41, n. 1, p. 73-9, 2013-Jan.
Rights: fechado
Identifier DOI: 10.1177/0192623312447541
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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