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Type: Artigo de periódico
Title: Nanoemulsions And Nanoparticles For Non-melanoma Skin Cancer: Effects Of Lipid Materials.
Author: Severino, P
Fangueiro, J F
Ferreira, S V
Basso, R
Chaud, M V
Santana, M H A
Rosmaninho, A
Souto, E B
Abstract: Basal cell carcinomas and squamous cell carcinomas are non-melanoma skin cancers reported to be among the most common malignancies, being responsible for high human morbidity. Conventional chemotherapy applied to these conditions shows non-specific targeting, thus severe adverse side effects are also commonly reported. New therapeutic strategies based on nanoparticulates technology have emerged as alternatives for site specific chemotherapy. Among the different types of nanoparticulates, lipid nanoemulsions and nanoparticles have several advantages for topical delivery of poorly soluble chemotherapeutics. These particles show sustained drug release and protection of loaded drugs from chemical degradation. This technology is promising to enhance the intracellular concentration of drugs and consequently reduce the cytotoxicity of skin chemotherapy.
Subject: Antineoplastic Agents
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
Drug Carriers
Skin Neoplasms
Citation: Clinical & Translational Oncology : Official Publication Of The Federation Of Spanish Oncology Societies And Of The National Cancer Institute Of Mexico. v. 15, n. 6, p. 417-24, 2013-Jun.
Rights: fechado
Identifier DOI: 10.1007/s12094-012-0982-0
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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