Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200443
Type: Artigo de periódico
Title: The Impact Of Oxidative Stress In Thiamine Deficiency: A Multifactorial Targeting Issue.
Author: Hazell, Alan S
Faim, Samantha
Wertheimer, Guilherme
Silva, Vinicius R
Marques, Cleiton S
Abstract: Thiamine (vitamin B1) deficiency, the underlying cause of Wernicke-Korsakoff syndrome, is associated with the development of focal neuronal loss in vulnerable areas of the brain. Although the actual mechanism(s) that lead to the selective histological lesions characteristic of this disorder remain unresolved, oxidative stress has been shown to play a major role in its pathophysiology. In this review, the multifactorial influence of oxidative stress on a variety of processes known to take part in the development of structural lesions in TD including excitotoxicity, neuroinflammation, blood-brain barrier integrity, mitochondrial integrity, apoptosis, nucleic acid function, and neural stem cells will be discussed, and therapeutic strategies undertaken for treating neurodegeneration examined which may have an impact on the future treatment of this important vitamin deficiency.
Subject: Animals
Apoptosis
Blood-brain Barrier
Humans
Mitochondria
Oxidative Stress
Thiamine Deficiency
Rights: fechado
Identifier DOI: 10.1016/j.neuint.2013.01.009
Address: http://www.ncbi.nlm.nih.gov/pubmed/23333339
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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