Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200442
Type: Artigo de periódico
Title: Protective Effects Of L-carnitine And Piracetam Against Mitochondrial Permeability Transition And Pc3 Cell Necrosis Induced By Simvastatin.
Author: Costa, Rute A P
Fernandes, Mariana P
de Souza-Pinto, Nadja C
Vercesi, Aníbal E
Abstract: Mitochondrial oxidative stress followed by membrane permeability transition (MPT) has been considered as a possible mechanism for statins cytotoxicity. Statins use has been associated with reduced risk of cancer incidence, especially prostate cancer. Here we investigated the pathways leading to simvastatin-induced prostate cancer cell death as well as the mechanisms of cell death protection by l-carnitine or piracetam. These compounds are known to prevent and/or protect against cell death mediated by oxidative mitochondrial damage induced by a variety of conditions, either in vivo or in vitro. The results provide evidence that simvastatin induced MPT and cell necrosis were sensitive to either l-carnitine or piracetam in a dose-dependent fashion and mediated by additive mechanisms. When combined, l-carnitine and piracetam acted at concentrations significantly lower than they act individually. These results shed new light into both the cytotoxic mechanisms of statins and the mechanisms underlying the protection against MPT and cell death by the compounds l-carnitine and piracetam.
Subject: Carnitine
Cell Line, Tumor
Cyclosporine
Drug Synergism
Humans
Mitochondria
Mitochondrial Membrane Transport Proteins
Necrosis
Piracetam
Simvastatin
Superoxides
Rights: fechado
Identifier DOI: 10.1016/j.ejphar.2013.01.001
Address: http://www.ncbi.nlm.nih.gov/pubmed/23333250
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.