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Type: Artigo de periódico
Title: Evaluation Of The Efficacy And Safety Of Botulinum Toxin Type A To Induce Temporary Ptosis In Dogs.
Author: Bittencourt, Maura Krähembühl Wanderley
de Vasconcellos, José Paulo Cabral
Bittencourt, Matheus Domingues
Malagó, Rodolfo
Bacellar, Marianna
Abstract: To verify the safety and efficacy of botulinum toxin type A (BoNT/A) to promote protective ptosis in dogs. In this prospective interventional study, a total of 10 dogs underwent transcutaneous anterior chemodenervation of levator palpebral superioris with 15 U of BoNT/A. The systemic changes, ocular mobility, visual function, intraocular pressure (IOP), tear production, and the onset, degree, and duration of ptosis were evaluated on a daily basis during the first 7 days and on days 14, 21, and 28 after application. The onset of the clinical effect was observed between 2 and 3 days after application of the toxin; the time taken for maximum ptosis to develop varied from 4 to 7 days (mean 5 days) and the average duration of the toxin effect was 21 days. The mean percentage reduction in palpebral fissure height was 42.859% (SD±35.714%-59.821%). There was not a statistically significant difference in IOP before and after the BoNT/A application (P=0.974), or lacrimal production evaluation (P=0.276). There was no change in ocular mobility and no other adverse effect was observed in association with the administration of the study drug. The application of BoNT/A into the levator palpebral superioris muscle in dogs was effective and safe to promote protective ptosis with a temporary covering of the cornea.
Subject: Animals
Botulinum Toxins, Type A
Eye Movements
Intraocular Pressure
Neuromuscular Agents
Prospective Studies
Time Factors
Citation: Journal Of Ocular Pharmacology And Therapeutics : The Official Journal Of The Association For Ocular Pharmacology And Therapeutics. v. 29, n. 4, p. 431-6, 2013-May.
Rights: fechado
Identifier DOI: 10.1089/jop.2012.0119
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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