Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200426
Type: Artigo de periódico
Title: Taurine Supplementation Improves Liver Glucose Control In Normal Protein And Malnourished Mice Fed A High-fat Diet.
Author: Batista, Thiago M
Ribeiro, Rosane A
da Silva, Priscilla M R
Camargo, Rafael L
Lollo, Pablo C B
Boschero, Antonio C
Carneiro, Everardo M
Abstract: Poor nutrition during the perinatal period is associated with an increased risk for metabolic syndrome in adulthood. Taurine (TAU) regulates β-cell function and glucose homeo-stasis. Here, we assessed the effects of TAU supplementation upon adiposity and glucose control in malnourished mice fed a high-fat diet (HFD). Weaned male C57BL/6J mice were fed a control (14% protein - C) or a protein-restricted (6% protein - R) diet for 6 weeks. Afterwards, mice received or not an HFD for 8 weeks (CH and RH). Half of the HFDmice were supplemented with 5% TAU after weaning (CHT and RHT). Protein restriction led to typical malnutrition features. HFD increased body weight, adiposity, and led to hyperleptinemia, hyperphagia, glucose intolerance, and higher liver glucose output in RH and CH groups. Fasted R mice showed higher plasma adiponectin levels and increased phosphorylation of the AMP-activated protein kinase (p-AMPK) in the liver. These parameters were reduced in RH mice and increased p-AMPK persisted in RHT. TAU prevented obesity and improved glucose tolerance only in CHT, but liver glucose control was ameliorated in both supplemented groups. Better CHT liver glucose control was linked to increased Akt (thymoma viral proto-oncogene/protein kinase B) phosphorylation. Malnourished mice fed an HFD developed obesity, glucose intolerance, and increased liver glucose output. TAU preserved only normal liver glucose control in RHT mice, an effect associated with increased liver p-AMPK content.
Subject: Amp-activated Protein Kinases
Adiponectin
Adiposity
Amino Acids
Animals
Blood Glucose
Body Weight
Diet, High-fat
Dietary Supplements
Glucose Intolerance
Leptin
Liver
Male
Malnutrition
Mice
Mice, Inbred C57bl
Phosphorylation
Proto-oncogene Proteins C-akt
Taurine
Rights: fechado
Identifier DOI: 10.1002/mnfr.201200345
Address: http://www.ncbi.nlm.nih.gov/pubmed/23280999
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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