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Type: Artigo de periódico
Title: Characterization Of Semi-solid Self-emulsifying Drug Delivery Systems (sedds) Of Atorvastatin Calcium By Raman Image Spectroscopy And Chemometrics.
Author: Breitkreitz, Márcia C
Sabin, Guilherme P
Polla, Griselda
Poppi, Ronei J
Abstract: A methodology based on Raman image spectroscopy and chemometrics for homogeneity evaluation of formulations containing atorvastatin calcium in Gelucire(®) 44/14 is presented. In the first part of the work, formulations with high amounts of Gelucire(®) 44/14 (80%) and solvents of different polarities (diethylene glycol monoethyl ether, propyleneglycol, propylene glycol monocaprylate and glyceryl mono/dicaprylate/caprate) were prepared for miscibility screening evaluation by classical least squares (CLS). It was observed that Gelucire(®) 44/14 presented higher affinity for the lipophilic solvents glyceryl mono/dicaprylate/caprate and propylene glycol monocaprylate, whose samples were observed to be homogeneous, and lower affinity for the hydrophilic solvents diethylene glycol monoethyl ether and propyleneglycol, whose samples were heterogeneous. In the second part of the work, the ratio of glyceryl mono/dicaprylate/caprate and Gelucire(®) 44/14 was determined based on studies in water and allowed the selection of the proportions of these two excipients in the preconcentrate that provided supersaturation of atorvastatin upon dilution. The preconcentrate was then evaluated for homogeneity by partial least squares (PLS) and an excellent miscibility was observed in this proportion as well. Therefore, it was possible to select a formulation that presented simultaneously homogeneous preconcentrate and solubility enhancement in water by Raman image spectroscopy and chemometrics.
Subject: Combinatorial Chemistry Techniques
Drug Carriers
Drug Compounding
Heptanoic Acids
Hydrophobic And Hydrophilic Interactions
Multivariate Analysis
Phase Transition
Polyethylene Glycols
Regression Analysis
Spectrum Analysis, Raman
Surface Properties
Surface-active Agents
Citation: Journal Of Pharmaceutical And Biomedical Analysis. v. 73, p. 3-12, 2013-Jan.
Rights: fechado
Identifier DOI: 10.1016/j.jpba.2012.03.054
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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