Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200410
Type: Artigo de periódico
Title: Serological Profiles And Evaluation Of Parasitaemia By Pcr And Blood Culture In Individuals Chronically Infected By Trypanosoma Cruzi Treated With Benzonidazole.
Author: Aguiar, Camila
Batista, Angelica M
Pavan, Tycha B S
Almeida, Eros A
Guariento, Maria E
Wanderley, Jamiro S
Costa, Sandra C B
Abstract: To evaluate the serological and parasitological status of patients with chronic Chagas disease (CD) after chemotherapy with benzonidazole. Retrospective study of patients treated with benzonidazole (5 mg/kg/day for 60 days) between 1980 and 2010. Twenty-nine patients who had CD confirmed by two reagent immunological tests and/or one positive xenodiagnosis before treatment were included. Conventional serology (ELISA and IIF) and parasitological tests (haemoculture and N-PCR) were performed. At the time of treatment, the mean age of patients was 36 ± 7.24 years (20-39 years) and the time post-treatment varied from 1 to 29 years. After chemotherapy, all individuals had reagent ELISA and 93.1% had positive results for the IIF test. T. cruzi DNA was detected by N-PCR in 48.3%. Negative results were observed in 41.4% and inconclusive ones in 10.3%. Haemoculture was negative for all individuals. Our results suggest that N-PCR may be useful in the early identification of therapeutic failure of CD. Although it is difficult to determine parasitological cure in negative N-PCR cases, we can infer that this condition represents a declination of parasitaemia as a favourable consequence of aetiological treatment.
Subject: Adult
Age Factors
Antibodies, Protozoan
Chagas Disease
Chronic Disease
Dna, Protozoan
Enzyme-linked Immunosorbent Assay
Female
Fluorescent Antibody Technique, Indirect
Humans
Male
Nitroimidazoles
Parasitemia
Polymerase Chain Reaction
Retrospective Studies
Treatment Failure
Trypanocidal Agents
Trypanosoma Cruzi
Young Adult
Rights: fechado
Identifier DOI: 10.1111/j.1365-3156.2011.02936.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/22212647
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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