Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200407
Type: Artigo de periódico
Title: Weight Loss And Resting Energy Expenditure In Patients With Chronic Hepatitis C Before And During Standard Treatment.
Author: Fioravante, Milena
Alegre, Sarah Monte
Marin, Daniela Miguel
Lorena, Sonia Leticia Silva
Pereira, Tiago Sevá
Soares, Elza Cotrim
Abstract: Infection with hepatitis C virus (HCV) is a serious public health problem worldwide. In clinical studies, weight loss has been reported in 11% to 29% of patients treated with pegylated interferon-α-2a/2b. Few reports have tried to explain such a weight loss. The aim of this study was to evaluate nutritional status, body composition, and resting energy expenditure (REE) in patients with chronic hepatitis C before and during treatment with pegylated interferon and ribavirin. This was a prospective study with the evaluation of patients with hepatitis C virus before and after 12 wk of treatment with pegylated interferon and ribavirin. The evaluation consisted of anthropometry (weight, height, body mass index, and waist circumference), and body composition was determined by bioelectrical impedance analysis. The REE of each individual was obtained by indirect calorimetry. To compare the two phases of treatment, the Wilcoxon test was used. The significance level was 5%. Subjects had significant weight loss during treatment with a consequent decrease in body mass index. This weight decrease was accompanied by a significant decrease in body fat and no decrease in fat-free mass. There was a significant decrease in energy intake as assessed by 24-h recall. However, there was no change in REE and in REE corrected for fat-free mass. Our study of patients with hepatitis C treatment showed that these patients had significant weight loss and this was not associated with changes in energy expenditure. However, we observed a significant decrease in energy intake, pointing to a possible need for intervention measures to decrease the damage.
Subject: Adipose Tissue
Adult
Antiviral Agents
Basal Metabolism
Body Fluid Compartments
Body Mass Index
Diet Records
Energy Intake
Female
Hepatitis C, Chronic
Humans
Interferon-alpha
Male
Middle Aged
Polyethylene Glycols
Prospective Studies
Recombinant Proteins
Ribavirin
Standard Of Care
Statistics, Nonparametric
Weight Loss
Rights: fechado
Identifier DOI: 10.1016/j.nut.2011.08.010
Address: http://www.ncbi.nlm.nih.gov/pubmed/22196981
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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