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Type: Artigo de periódico
Title: Current State-of-art And New Trends On Lipid Nanoparticles (sln And Nlc) For Oral Drug Delivery.
Author: Severino, Patrícia
Andreani, Tatiana
Macedo, Ana Sofia
Fangueiro, Joana F
Santana, Maria Helena A
Silva, Amélia M
Souto, Eliana B
Abstract: Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs and other active ingredients. These have been exploited for many features in the field of pharmaceutical technology. Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size and increasing their GIT residence time. In addition, lipid nanoparticles may also protect the loaded drugs from chemical and enzymatic degradation and gradually release drug molecules from the lipid matrix into blood, resulting in improved therapeutic profiles compared to free drug. Therefore, due to their physiological and biodegradable properties, lipid molecules may decrease adverse side effects and chronic toxicity of the drug-delivery systems when compared to other of polymeric nature. This paper highlights the importance of lipid nanoparticles to modify the release profile and the pharmacokinetic parameters of drugs when administrated through oral route.
Rights: aberto
Identifier DOI: 10.1155/2012/750891
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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