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Type: Artigo de periódico
Title: Characterization Of Pulmonary And Systemic Inflammatory Responses Produced By Lung Re-expansion After One-lung Ventilation.
Author: Leite, Camila Ferreira
Calixto, Marina Ciarallo
Toro, Ivan Felizardo Contrera
Antunes, Edson
Mussi, Ricardo Kalaf
Abstract: To characterize the pulmonary and systemic inflammatory responses of rats undergoing 1-hour or 3-hour one-lung ventilation (OLV) with subsequent 1-hour lung re-expansion. A prospective, randomized, controlled animal experiment. University laboratory. Thirty male Wistar rats were used. Rats were subjected to 1- or 3-hour OLV followed or not by 1-hour lung re-expansion. Control rats received no ventilation. Pulmonary protein extravasation, pulmonary myeloperoxidase (MPO) activity, cytokine levels in serum and bronchoalveolar lavage (BAL), counts of total and differential cells in BAL fluid, gasometric data, and mean arterial blood pressure (MABP) were all evaluated. Bronchial occlusion for 1 or 3 hours with no lung re-expansion did not significantly change the protein extravasation in the right and left lungs compared with the control group. However, rats submitted to 1- or 3-hour OLV followed by lung re-expansion exhibited pulmonary edema formation and neutrophil recruitment as well as a higher MPO activity in comparison with control rats. Increased levels of interleukin (IL)-6, IL-1β, and tumor necrosis factor-α in BAL fluid were observed. Increased levels of IL-6 and IL-10 in serum also were detected. Blood gas and MABP did not differ between groups. Lung re-expansion after bronchial occlusion evokes an acute lung inflammatory response, which has been shown to be more pronounced in long periods of bronchial occlusion in terms of cytokine inflammatory response. In addition, the magnitude of this inflammatory response also can be detected systemically.
Subject: Animals
Bronchoalveolar Lavage Fluid
Carbon Dioxide
Inflammation Mediators
Partial Pressure
Pulmonary Edema
Rats, Wistar
Respiration, Artificial
Systemic Inflammatory Response Syndrome
Time Factors
Citation: Journal Of Cardiothoracic And Vascular Anesthesia. v. 26, n. 3, p. 427-32, 2012-Jun.
Rights: fechado
Identifier DOI: 10.1053/j.jvca.2011.09.028
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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