Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200379
Type: Artigo de periódico
Title: Platelet Associated Igg May Be Related With Thrombocytopenia In Patients With Myelodysplastic Syndromes.
Author: Gilli, Simone Cristina Olenscki
de Souza Medina, Samuel
de Castro, Vagner
Fernandes, Luís Gustavo Romani
Saad, Sara Teresinha Olalla
Abstract: Thrombocytopenia is common in patients with myelodysplastic syndromes (MDS) and immune destruction of platelets could be an important factor for its occurrence. We prospectively analyzed platelet-associated IgG (PAIgG) through platelet immunofluorescence test (PIFT), mean platelet volume (MPV), platelet size deviation width (PDW) and glycocalicin index (GCI) of 54 patients with MDS, classified according to the International Prognostic Scoring System (IPSS). Thrombocytopenia (platelet count<100×10(9)/L) was correlated with a higher amount of PAIgG, significantly higher MPV and increased GCI. In addition, worse prognosis IPSS groups were associated with a higher positivity of PIFT, which could be indicative of advanced disease.
Subject: Aged
Blood Platelets
Female
Fluorescent Antibody Technique, Direct
Humans
Immunoglobulin G
Male
Middle Aged
Myelodysplastic Syndromes
Prevalence
Prognosis
Prospective Studies
Thrombocytopenia
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2011.10.003
Address: http://www.ncbi.nlm.nih.gov/pubmed/22129476
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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