Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200363
Type: Artigo de periódico
Title: Alterations In The Achilles Tendon After Inflammation In Surrounding Tissue.
Author: Vieira, Cristiano Pedrozo
Guerra, Flávia da Ré
de Oliveira, Letícia Prado
de Almeida, Marcos Dos Santos
Pimentel, Edson Rosa
Abstract: To analyze the characteristics of the Achilles tendon of rats after induction of localized inflammation in the rat paw. IN OUR STUDY THREE GROUPS WERE USED: inflamed group with carrageenan in rat paw (G1); saline group (G2) and control group (G3). After 4 hours the animals were euthanized and the Achilles tendon removed. No significant differences were observed in the analysis of non-collagenous proteins, glycosaminoglycans and hydroxyproline in the groups but a tendency of reduction was verified in G1. As regards the organization of collagen molecules, no differences were observed between groups. With respect to MMPs activity, a stronger presence of the active isoform of MMP-2 in G1 was observed, suggesting that the remodeling was occurring. Thus, we conclude that the inflammatory process in rat paw may affect the remodeling of tendons located near the inflamed site. Level of Evidence I, Prognostic Studies - Investigating the Effect of a Patient Characteristic on the Outcome of Disease.
Subject: Achilles Tendon/injuries
Carrageenan
Inflammation
Rights: aberto
Identifier DOI: 10.1590/S1413-78522012000500004
Address: http://www.ncbi.nlm.nih.gov/pubmed/24453615
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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