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Type: Artigo de periódico
Title: Radioprotective Effect Of Sodium Selenite On Bone Repair In The Tibia Of Ovariectomized Rats.
Author: de Freitas, Deborah Queiroz
Ramos-Perez, Flávia Maria de Moraes
Neves, Ellen Gaby
Marques, Marcelo Rocha
Bóscolo, Frab Norberto
de Almeida, Solange Maria
Abstract: This study evaluated protection by selenium (Se) in the bone repair process in ovariectomized rats after irradiation. For such purpose, 80 ovariectomized female Wistar rats were randomly divided into 4 experimental groups: ovariectomized (Ov), Ov/Se, Ov/irradiated (Irr) and Ov/ Se/Irr. A bone defect was created on the tibia of all animals 40 days after ovariectomy. Two days after surgery, only the Ov/Se and Ov/Se/Irr rats received 0.8 mg Se/kg. Three days after surgery, only the Ov/Irr and Ov/Se/Irr rats received 10 Gy of x-rays on the lower limb region. The animals were euthanized at 7, 14, 21 and 28 days after surgery to assess the repair process, which was evaluated by analysis of trabecular bone number (Masson Trichrome) and birefringence analysis (Picrosirius). It was possible to observe a delay in the bone repair process in the ovariectomized/irradiated group and similarity between the ovariectomized, Ov/Se and Ov/Se/Irr groups. In conclusion, sodium selenite exerted a radioprotective effect in the bone repair of tibia of ovariectomized rats without toxicity.
Subject: Animals
Azo Compounds
Bone Density
Bone Diseases
Bone Regeneration
Bone Remodeling
Coloring Agents
Eosine Yellowish-(ys)
Image Processing, Computer-assisted
Methyl Green
Radiation Dosage
Radiation-protective Agents
Random Allocation
Rats, Wistar
Selenious Acid
Time Factors
Rights: fechado
Identifier DOI: 
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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