Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200311
Type: Artigo de periódico
Title: Disappearance Of Cerebrospinal Fluid Oligoclonal Bands After Natalizumab Treatment Of Multiple Sclerosis Patients.
Author: von Glehn, Felipe
Farias, Alessandro S
de Oliveira, Augusto C Penalva
Damasceno, Alfredo
Longhini, Ana Leda F
Oliveira, Elaine C
Damasceno, Benito P
Santos, Leonilda M B
Brandão, Carlos Otávio
Abstract: Intrathecal immunoglobulin synthesis in an oligoclonal pattern is the most common immunologic abnormality detected in MS patients. Various treatments, such as immunomodulators and immunosuppressors, have not been found to modify it. Natalizumab hinders migration of encephalitogenic T-cells into the central nervous system (CNS), reducing inflammatory response. Its impact on CSF oligoclonal bands (OCBs) has not been demonstrated. This report describes its effect in four out of six patients with multiple sclerosis after a mean of 10 infusions: the CSF was negative for OCBs at the second lumbar puncture. In conclusion, natalizumab treatment can reduce CSF OCBs to undetectable levels, although the clinical significance of this observation is not yet known.
Subject: Adult
Antibodies, Monoclonal, Humanized
B-lymphocytes
Cd4-positive T-lymphocytes
Female
Humans
Male
Multiple Sclerosis, Relapsing-remitting
Oligoclonal Bands
Young Adult
Rights: fechado
Identifier DOI: 10.1177/1352458511428465
Address: http://www.ncbi.nlm.nih.gov/pubmed/22041091
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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