Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200253
Type: Artigo de periódico
Title: Serum Levels And Mesenteric Fat Tissue Expression Of Adiponectin And Leptin In Patients With Crohn's Disease.
Author: Rodrigues, V S
Milanski, M
Fagundes, J J
Torsoni, A S
Ayrizono, M L S
Nunez, C E C
Dias, C B
Meirelles, L R
Dalal, S
Coy, C S R
Velloso, L A
Leal, R F
Abstract: Crohn's disease (CD) is characterized by inflammation and an aetiology that is still unknown. Hypertrophy of mesenteric fat is a reflection of disease activity, as this fat covers the entire length of the affected area. Adipocytes synthesize leptin and adiponectin, adipocytokines responsible for pro- and anti-inflammatory effects. Therefore, we evaluated serum levels of adiponectin and leptin, as well as mesenteral expression of adiponectin in active CD and those in remission. Sixteen patients with ileocaecal CD followed at the Outpatient Clinic, Coloproctology Unit of University of Campinas Clinical Hospital, participated in the study. Analysis of serum adiponectin and leptin by enzyme-linked immunosorbent assay was performed in patients with active CD (ACD group), remission CD (RCD group) and in six healthy controls. Ten patients with active ileocaecal CD (FCD group) and eight patients with non-inflammatory disease selected for surgery were also studied. The specimens were snap-frozen and the expression of adiponectin was determined by immunoblot of protein extracts. Serum C-reactive protein levels were higher in the ACD group when compared to the others and no difference of body mass index was observed between the groups. Serum adiponectin was lower in the ACD group when compared to control, but no differences were seen when comparing the ACD and RCD groups. Mesenteric adiponectin expression was lower in the FCD group when compared to the FC group. Serum leptin was similar in all groups. The lower levels of serum and mesenteric adiponectin in active CD suggest a defective regulation of anti-inflammatory pathways in CD pathogenesis.
Subject: Adiponectin
Adipose Tissue
Adolescent
Adult
Antigens, Cd
Body Mass Index
C-reactive Protein
Crohn Disease
Female
Humans
Leptin
Male
Mesentery
Middle Aged
Young Adult
Rights: fechado
Identifier DOI: 10.1111/j.1365-2249.2012.04660.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/23121676
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_23121676.pdf770.4 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.