Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200231
Type: Artigo de periódico
Title: Association Between The Ivs4g>t Mutation In The Tcf7l2 Gene And Susceptibility To Diabetes In Cystic Fibrosis Patients.
Author: Furgeri, Daniela Tenório
Marson, Fernando Augusto de Lima
Ribeiro, Antonio Fernando
Bertuzzo, Carmen Silvia
Abstract: Clinical complications appear to be a decisive factor for the prognosis of patients. Diabetes is an important complication of cystic fibrosis(CF). In our study we evaluated the association between the IVS4G>T mutation in the TCF7L2 gene with the presence of diabetes in patients with CF. We evaluated 145 patients with CF in relation to the genotype of the IVS4G>T mutation. For this, the PCR method associated with specific enzyme digestion was used. The genotypes G/G, G/T and T/T were observed to have frequencies of 54 (37.2%), 78 (53.8%) and 13 (9%), respectively. There was no association between genotype and the occurrence of diabetes among patients. In our sample, no association was found between the IVS4G>T mutation in the TCF7L2 gene and diabetes.
Subject: Brazil
Child
Comorbidity
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Diabetes Mellitus
Female
Gene Frequency
Genetic Predisposition To Disease
Genotype
Humans
Male
Mutation
Polymorphism, Single Nucleotide
Transcription Factor 7-like 2 Protein
Rights: fechado
Identifier DOI: 10.1186/1756-0500-5-561
Address: http://www.ncbi.nlm.nih.gov/pubmed/23050589
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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