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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleComparison Of Endotoxin Levels Found In Primary And Secondary Endodontic Infections.pt_BR
dc.contributor.authorGomes, Brenda P F Apt_BR
dc.contributor.authorEndo, Marcos Spt_BR
dc.contributor.authorMartinho, Frederico Cpt_BR
unicamp.authorBrenda P F A Gomes, Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas, São Paulo, SP, Brazil. bpgomes@fop.unicamp.brpt_BR
unicamp.author.externalMarcos S Endo,pt
unicamp.author.externalFrederico C Martinho,pt
dc.subjectAsymptomatic Diseasespt_BR
dc.subjectDna, Bacterialpt_BR
dc.subjectDental Pulp Cavitypt_BR
dc.subjectDental Pulp Diseasespt_BR
dc.subjectDental Pulp Necrosispt_BR
dc.subjectEndotoxinspt_BR
dc.subjectFusobacterium Infectionspt_BR
dc.subjectFusobacterium Nucleatumpt_BR
dc.subjectGram-negative Bacterial Infectionspt_BR
dc.subjectHumanspt_BR
dc.subjectLimulus Testpt_BR
dc.subjectLipopolysaccharidespt_BR
dc.subjectPain Measurementpt_BR
dc.subjectPeriapical Periodontitispt_BR
dc.subjectPolymerase Chain Reactionpt_BR
dc.subjectPorphyromonas Endodontalispt_BR
dc.subjectPrevotella Nigrescenspt_BR
dc.subjectRecurrencept_BR
dc.subjectRetreatmentpt_BR
dc.subjectSuppurationpt_BR
dc.subjectTreponemapt_BR
dc.subjectTreponema Denticolapt_BR
dc.subjectTreponemal Infectionspt_BR
dc.description.abstractThis clinical study was conducted to compare the levels of endotoxins (lipopolysaccharides [LPSs]) found in primary and secondary endodontic infections with apical periodontitis by correlating LPS contents with clinical/radiographic findings. In addition, the presence of target gram-negative anaerobic bacteria was also investigated. Samples were taken from 15 root canals with primary infections and 15 with secondary infections by using paper points. The limulus amebocyte lysate assay was used to quantify endotoxins, and the polymerase chain reaction technique (16S rDNA) was used for bacterial investigation. Endotoxins were detected in 100% of the root canal samples collected from primary (15/15) and secondary (15/15) infections with median values of 7.49 EU/mL and 3.96 EU/mL, respectively (P < .05). The median value of endotoxins found in the presence of clinical symptoms was significantly higher than in asymptomatic teeth with primary infections (P < .05). A positive correlation was found between endotoxin contents and a larger size of the radiolucent area (>3 mm) (P < .05). Prevotella nigrescens (10/15, 4/15), Fusobacterium nucleatum (5/15, 1/15), Treponema denticola (3/15, 1/15), and Treponema socranskii (5/15, 1/15) were detected in teeth with primary and secondary infections, respectively. P. endodontalis was present only in teeth with primary infections (5/15). Teeth with primary endodontic infections had higher contents of endotoxins and a more complex gram-negative bacterial community than teeth with secondary infections. Moreover, the levels of endotoxins were related to the severity of bone destruction in periapical tissues as well as the development of clinical features in teeth with primary infections.en
dc.relation.ispartofJournal Of Endodonticspt_BR
dc.relation.ispartofabbreviationJ Endodpt_BR
dc.date.issued2012-Augpt_BR
dc.identifier.citationJournal Of Endodontics. v. 38, n. 8, p. 1082-6, 2012-Aug.pt_BR
dc.language.isoengpt_BR
dc.description.volume38pt_BR
dc.description.firstpage1082-6pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1878-3554pt_BR
dc.identifier.doi10.1016/j.joen.2012.04.021pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22794210pt_BR
dc.date.available2015-11-27T13:28:43Z-
dc.date.accessioned2015-11-27T13:28:43Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:28:43Z (GMT). No. of bitstreams: 1 pmed_22794210.pdf: 111906 bytes, checksum: 276aa2d6080d14067fbd64605e40bf62 (MD5) Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200104-
dc.identifier.idPubmed22794210pt_BR
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