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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSchistosoma Mansoni: In Vitro Schistosomicidal Activity Of Essential Oil Of Baccharis Trimera (less) Dc.pt_BR
dc.contributor.authorde Oliveira, Rosimeire Nunespt_BR
dc.contributor.authorRehder, Vera Lúcia Garciapt_BR
dc.contributor.authorSantos Oliveira, Adriana Spt_BR
dc.contributor.authorJúnior, Ílio Montanaript_BR
dc.contributor.authorde Carvalho, João Ernestopt_BR
dc.contributor.authorde Ruiz, Ana Lúcia Tasca Goispt_BR
dc.contributor.authorJeraldo, Veronica de Lourdes Sierpept_BR
dc.contributor.authorLinhares, Arício Xavierpt_BR
dc.contributor.authorAllegretti, Silmara Marquespt_BR
unicamp.authorRosimeire Nunes de Oliveira, Instituto de Biologia, Depto. de Biologia Animal, Universidade Estadual de Campinas, Unicamp, SP, Brazil. rosy_biologa@yahoo.com.brpt_BR
unicamp.author.externalVera Lúcia Garcia Rehder,pt
unicamp.author.externalAdriana S Santos Oliveira,pt
unicamp.author.externalÍlio Montanari Júnior,pt
unicamp.author.externalJoão Ernesto de Carvalho,pt
unicamp.author.externalAna Lúcia Tasca Gois de Ruiz,pt
unicamp.author.externalVeronica de Lourdes Sierpe Jeraldo,pt
unicamp.author.externalArício Xavier Linhares,pt
unicamp.author.externalSilmara Marques Allegretti,pt
dc.subjectAnimalspt_BR
dc.subjectBaccharispt_BR
dc.subjectBiomphalariapt_BR
dc.subjectCell Linept_BR
dc.subjectDose-response Relationship, Drugpt_BR
dc.subjectFemalept_BR
dc.subjectGas Chromatography-mass Spectrometrypt_BR
dc.subjectHumanspt_BR
dc.subjectKeratinocytespt_BR
dc.subjectMalept_BR
dc.subjectMicept_BR
dc.subjectMicroscopy, Electron, Scanningpt_BR
dc.subjectMovementpt_BR
dc.subjectOils, Volatilept_BR
dc.subjectOvipositionpt_BR
dc.subjectPlant Extractspt_BR
dc.subjectSchistosoma Mansonipt_BR
dc.subjectSchistosomiasis Mansonipt_BR
dc.subjectSchistosomicidespt_BR
dc.subjectSex Factorspt_BR
dc.subjectSpecific Pathogen-free Organismspt_BR
dc.description.abstractSchistosomiasis is a chronic parasitic disease caused by the trematode species Schistosoma mansoni. Chemotherapy is the only immediate recourse to minimize the prevalence and incidence of this disease worldwide. At present, praziquantel (PZQ) is the drug of choice for the treatment of all forms of schistosomiasis. However, dependence on a single drug is concern because some strains can become resistant. In this context, medicinal plants become potential candidates as sources of new drug prototypes. This study provides findings on the schistosomicidal activity of the essential oil of Baccharis trimera in in vitro assays. During the assays parameters such as motility of adult worms, oviposition, morphological changes on the tegument and especially the mortality rate of adult worms of the BH strain were evaluated. The assays, which were carried out with four concentrations - 24, 48, 91 and 130 μg/mL - of the essential oil, have shown a promising activity regarding the parameters under study. It was possible to notice a significant decline in the motility of the worms and a mortality rate of 100% 30 h after they had been exposed to the essential oil in the concentration of 130 μg/mL. Male worms were more susceptible, producing a dose-response effect within a smaller exposition period than female worms. In what refers to morphological changes, the essential oil of B. trimera induced a peeling on the tegument surface, as well as the destruction of tubercles and spines, which resulted in smooth areas on the body surface. The essential oil also caused tegument destruction in female worms, in addition to destruction of the oral and acetabular suckers. It is the first time that the schistosomicidal activity has been reported for essential oil of B. trimera (less) DC.en
dc.relation.ispartofExperimental Parasitologypt_BR
dc.relation.ispartofabbreviationExp. Parasitol.pt_BR
dc.date.issued2012-Octpt_BR
dc.identifier.citationExperimental Parasitology. v. 132, n. 2, p. 135-43, 2012-Oct.pt_BR
dc.language.isoengpt_BR
dc.description.volume132pt_BR
dc.description.firstpage135-43pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2012 Elsevier Inc. All rights reserved.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1090-2449pt_BR
dc.identifier.doi10.1016/j.exppara.2012.06.005pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22771865pt_BR
dc.date.available2015-11-27T13:28:42Z-
dc.date.accessioned2015-11-27T13:28:42Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:28:42Z (GMT). No. of bitstreams: 1 pmed_22771865.pdf: 1210347 bytes, checksum: e69e3620f139c94e26156c361b925596 (MD5) Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200097-
dc.identifier.idPubmed22771865pt_BR
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