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Type: Artigo de periódico
Title: Proteomic Profiling Of Skeletal Muscle In An Animal Model Of Overtraining.
Author: Gandra, Paulo Guimaraes
Valente, Richard Hemmi
Perales, Jonas
Pacheco, Antonio Guilherme Fonseca
Macedo, Denise Vaz
Abstract: Excessive training (i.e. overtraining, OT) may result in underperformance, which can be characterized by the time needed to re-establish performance (i.e. functional overreaching (FOR), nonfunctional overreaching, OT syndrome). The present study is an initial screening for proteins presenting altered abundance in the red (RG) and white (WG) portions of the gastrocnemius muscle from rats submitted to an OT protocol that induced FOR. In the RG, compared to the nontrained control, FOR demonstrated an increased abundance of proteins normally related to adaptation to endurance training (e.g. proteins of oxidative phosphorylation complexes, proteins related to lipid metabolism, antioxidants, and chaperones). In the WG, spots identified as mitochondrial aconitase and a component of the succinate dehydrogenase complex were downregulated in FOR, as were proteins related to myofibril stabilization; these latter were upregulated in the RG. This initial study shows that skeletal muscles with different fiber-type compositions respond differently to an OT period. Also, it is likely that actin-interacting proteins have an important role in muscle adaptation to endurance exercise.
Subject: Animals
Muscle Fibers, Fast-twitch
Muscle Fibers, Slow-twitch
Myosin Heavy Chains
Physical Conditioning, Animal
Physical Exertion
Rats, Wistar
Reactive Oxygen Species
Citation: Proteomics. v. 12, n. 17, p. 2663-7, 2012-Aug.
Rights: fechado
Identifier DOI: 10.1002/pmic.201200137
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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